PD 173212
Modify Date: 2024-01-15 00:13:19
PD 173212 structure
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Common Name | PD 173212 | ||
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| CAS Number | 217171-01-2 | Molecular Weight | 599.84600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C38H53N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PD 173212PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. |
| Name | (2S)-N-[(2S)-1-(tert-butylamino)-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-tert-butylphenyl)methyl-methylamino]-4-methylpentanamide |
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| Synonym | More Synonyms |
| Description | PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. |
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| Related Catalog | |
| Target |
IC50: 36 nM (VSCC)[1] |
| In Vitro | PD173212 (PD 173212, 300 nM) potently blocks recombinant B-class (N-type) calcium channel currents 78±7.8%, with an IC50 of 74 nM, by whole-cell voltage-clamp techniques. PD 173212 possesses selectivity for non L-type Ca2+ channels versus neuronal Na+, K+, and L-type Ca2+ channels[1]. |
| In Vivo | PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1]. |
| References |
| Molecular Formula | C38H53N3O3 |
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| Molecular Weight | 599.84600 |
| Exact Mass | 599.40900 |
| PSA | 70.67000 |
| LogP | 7.83360 |
| Storage condition | 2-8℃ |
| PD173212 |