Tigecycline

Modify Date: 2024-01-02 06:03:49

Tigecycline structure	Common Name	Tigecycline
	CAS Number	220620-09-7	Molecular Weight	585.649
	Density	1.5±0.1 g/cm3	Boiling Point	890.9±65.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₃₉N₅O₈	Melting Point	164-166°C
	MSDS	N/A	Flash Point	492.6±34.3 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Tigecycline

Tigecycline is a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.Target: AntibacterialTigecycline is active against a broad range of gram-negative and gram-positive bacterial species including clinically important multidrug-resistant nosocomial and community-acquired bacterial pathogens. Tigecycline has been shown to inhibit the translation elongation step by binding to the ribosome 30S subunit and preventing aminoacylated tRNAs to accommodate in the ribosomal A site [1]. Tigecycline has also been found to be effective for the treatment of community- as well as hospital-acquired and ventilator-associated pneumonia and bacteremia, sepsis with shock and urinary tract infections. Tigecycline appears to be a valuable treatment option for the management of superbugs, especially where conventional therapy has failed [2].Fifteen patients received tigecycline for 16 episodes of CPKP infection. The main infections were pneumonia (31%), urinary tract infection (31%), peritonitis (20%), catheter-related bacteraemia (12%), and meningitis (6%). Most infections were complicated with severe sepsis (44%), septic shock (12%), and/or bacteraemia (19%). The daily maintenance dose of tigecycline was 200 mg in 10 episodes and 100 mg in 6 episodes. The overall 30-day mortality rate was 25%. Univariate analysis showed that mortality was significantly associated (p < 0.01) with mean APACHE II and SOFA scores and the presence of immunosuppression, but not with the tigecycline dose [3].

Name	tigecycline
Synonym	More Synonyms

Description	Tigecycline is a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.Target: AntibacterialTigecycline is active against a broad range of gram-negative and gram-positive bacterial species including clinically important multidrug-resistant nosocomial and community-acquired bacterial pathogens. Tigecycline has been shown to inhibit the translation elongation step by binding to the ribosome 30S subunit and preventing aminoacylated tRNAs to accommodate in the ribosomal A site [1]. Tigecycline has also been found to be effective for the treatment of community- as well as hospital-acquired and ventilator-associated pneumonia and bacteremia, sepsis with shock and urinary tract infections. Tigecycline appears to be a valuable treatment option for the management of superbugs, especially where conventional therapy has failed [2].Fifteen patients received tigecycline for 16 episodes of CPKP infection. The main infections were pneumonia (31%), urinary tract infection (31%), peritonitis (20%), catheter-related bacteraemia (12%), and meningitis (6%). Most infections were complicated with severe sepsis (44%), septic shock (12%), and/or bacteraemia (19%). The daily maintenance dose of tigecycline was 200 mg in 10 episodes and 100 mg in 6 episodes. The overall 30-day mortality rate was 25%. Univariate analysis showed that mortality was significantly associated (p < 0.01) with mean APACHE II and SOFA scores and the presence of immunosuppression, but not with the tigecycline dose [3].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Alkaloid
References	[1]. Seputiene V, et al. Tigecycline - how powerful is it in the fight against antibiotic-resistant bacteria? Medicina (Kaunas). 2010;46(4):240-8. [2]. Bhattacharya M, et al. Tigecycline. J Postgrad Med. 2009 Jan-Mar;55(1):65-8. [3]. Moreno BB, et al. Tigecycline therapy for infections due to carbapenemase-producing Klebsiella pneumoniae in critically ill patients. Scand J Infect Dis. 2013 Dec 20.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

Natural Products >> Alkaloid

References

[1]. Seputiene V, et al. Tigecycline - how powerful is it in the fight against antibiotic-resistant bacteria? Medicina (Kaunas). 2010;46(4):240-8.

[2]. Bhattacharya M, et al. Tigecycline. J Postgrad Med. 2009 Jan-Mar;55(1):65-8.

[3]. Moreno BB, et al. Tigecycline therapy for infections due to carbapenemase-producing Klebsiella pneumoniae in critically ill patients. Scand J Infect Dis. 2013 Dec 20.

Density	1.5±0.1 g/cm3
Boiling Point	890.9±65.0 °C at 760 mmHg
Melting Point	164-166°C
Molecular Formula	C₂₉H₃₉N₅O₈
Molecular Weight	585.649
Flash Point	492.6±34.3 °C
Exact Mass	585.279846
PSA	205.76000
LogP	-1.30
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.675
Storage condition	Amber Vial, -20°C Freezer

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H319-H360
Precautionary Statements	P201-P280-P305 + P351 + P338-P308 + P313
Hazard Codes	Xn
Safety Phrases	S24/25
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
HS Code	3004909090

9-chloroacetami...

CAS#:156263-28-4

tert-Butylamine

CAS#:75-64-9

~89%

Tigecycline

CAS#:220620-09-7

Literature: SANDOZ AG Patent: WO2009/92680 A2, 2009 ; Location in patent: Page/Page column 7 ;

t-butylacetyl c...

CAS#:7065-46-5

9-Animominocycline

CAS#:149934-19-0

Tigecycline

CAS#:220620-09-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 10 p. 1459 - 1462

Precursor 4
CAS#:156263-28-4 9-chloroacetami... CAS#:75-64-9 tert-Butylamine CAS#:7065-46-5 t-butylacetyl c... CAS#:149934-19-0 9-Animominocycline
DownStream 0

HS Code	3004909090

WAY-GAR 936

TIGECYCLINE POWDER

9-t-Butylglycylamido-minocycline hydrate

2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-((((1,1-dimethylethyl)amino)acetyl)amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-

Tigercycline

(4S,4aS,5aR,12aS)-9-{[(tert-butylamino)acetyl]amino}-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

2-naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-

2-NAPHTHACENECARBOXAMIDE

(4S,4aS,5aR,12aS)-9-[(N-tert-Butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

Glycylcycline

(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-{[N-(2-methyl-2-propanyl)glycyl]amino}-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide

2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-

Tygacil

MFCD00935753

Tigecycline

TIGECYCLINE GLYCYLCYCLINE

Tegecycline

DC Chemicals Limited
China
Product Name: Tigecycline
Price: $450.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Tigecycline
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tigecycline
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Tigecycline

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