Tigecycline hydrate
Tigecycline hydrate structure
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Common Name | Tigecycline hydrate | ||
|---|---|---|---|---|
| CAS Number | 1229002-07-6 | Molecular Weight | 603.66400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H39N5O8.xH2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
Use of Tigecycline hydrateTigecycline hydrate is a broad spectrum glycylcycline antibiotic. Tigecycline hydrate is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline hydrate is active against resistant strains of Gram-positive and Gram-negative bacteria. |
| Name | (4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide,hydrate |
|---|---|
| Synonym | More Synonyms |
| Description | Tigecycline hydrate is a broad spectrum glycylcycline antibiotic. Tigecycline hydrate is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline hydrate is active against resistant strains of Gram-positive and Gram-negative bacteria. |
|---|---|
| Related Catalog |
| Molecular Formula | C29H39N5O8.xH2O |
|---|---|
| Molecular Weight | 603.66400 |
| Exact Mass | 603.29000 |
| PSA | 219.47000 |
| LogP | 2.48240 |
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H319-H360 |
| Precautionary Statements | P201-P305 + P351 + P338-P308 + P313 |
| RIDADR | NONH for all modes of transport |
| RTECS | QI7619500 |
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Tigecycline inhibits proliferation of Acanthamoeba castellanii.
Parasitol. Res. 114(3) , 1189-95, (2015) Acanthamoeba is an opportunistic protozoan parasite responsible for different diseases in humans, such as granulomatous amoebic encephalitis and amoebic keratitis. Tigecycline, a third-generation tetr... |
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Novel drug combination for Mycobacterium abscessus disease therapy identified in a Drosophila infection model.
J. Antimicrob. Chemother. 69(6) , 1599-607, (2014) Mycobacterium abscessus is known to be the most drug-resistant Mycobacterium and accounts for ∼80% of pulmonary infections caused by rapidly growing mycobacteria. This study reports a new Drosophila m... |
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Pharmacokinetics of intravenously administered tigecycline in eye compartments: an experimental study.
Graefes Arch. Clin. Exp. Ophthalmol. 252(12) , 1993-7, (2014) The purpose of this study was to evaluate the ocular distribution of intravenously administered tigecycline in a rabbit uveitis model.Tigecycline, which has a broad spectrum of activity against many g... |
| Tigecyclin |
| 9-t-Butylglycylamido-minocycline hydrate |
| Tigecycline hydrate |