NS-062
Modify Date: 2023-01-14 16:09:21
NS-062 structure
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Common Name | NS-062 | ||
|---|---|---|---|---|
| CAS Number | 2226257-92-5 | Molecular Weight | 623.483 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H30Cl2F2N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NS-062NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR; showed higher target specificity for EGFR than the corresponding Michael acceptors in a wide concentration range (0.1-10 μM); showed strong antiproliferative activity (IC50=0.19 μM) against erlotinib-resistant H1975 cells (L858R T790M doublemutant EGFR), NS-062 effectively inhibited EGFR (Y1068) autophosphorylation in H1975 cells at 0.5 uM, significantly suppressed tumor growth in a mouse xenograft model after oral administration. |
| Name | NS-062 |
|---|
| Description | NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR; showed higher target specificity for EGFR than the corresponding Michael acceptors in a wide concentration range (0.1-10 μM); showed strong antiproliferative activity (IC50=0.19 μM) against erlotinib-resistant H1975 cells (L858R T790M doublemutant EGFR), NS-062 effectively inhibited EGFR (Y1068) autophosphorylation in H1975 cells at 0.5 uM, significantly suppressed tumor growth in a mouse xenograft model after oral administration. |
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| References | References 1. Shindo N, et al. Nat Chem Biol. 2019 Jan 14. doi: 10.1038/s41589-018-0204-3. View Related Products by Target EGFR |
| Molecular Formula | C28H30Cl2F2N6O4 |
|---|---|
| Molecular Weight | 623.483 |