NS 5806
Modify Date: 2024-01-09 13:32:49
NS 5806 structure
|
Common Name | NS 5806 | ||
|---|---|---|---|---|
| CAS Number | 426834-69-7 | Molecular Weight | 574.07300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H8Br2F6N6O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of NS 5806NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2[1]. |
| Name | 1-[3,5-bis(trifluoromethyl)phenyl]-3-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea |
|---|---|
| Synonym | More Synonyms |
| Description | NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 5.3 nM (KV4.3)[1] |
| In Vitro | NS5806 (10 µM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 µM in CHO-K1 cells[1]. NS5806 activates canine transient outward potassium current (Ito) with an IC50 of 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on rabbit, respectively[2]. NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito[2]. |
| References |
| Molecular Formula | C16H8Br2F6N6O |
|---|---|
| Molecular Weight | 574.07300 |
| Exact Mass | 571.90300 |
| PSA | 99.08000 |
| LogP | 6.15990 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H413 |
| Precautionary Statements | P301 + P310 |
| Hazard Codes | T |
| RIDADR | UN 2811 6.1 / PGIII |
| ns5806 |