NS-3-008 hydrochloride
Modify Date: 2024-04-08 04:45:17
NS-3-008 hydrochloride structure
|
Common Name | NS-3-008 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1172854-54-4 | Molecular Weight | 269.817 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H24ClN3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NS-3-008 hydrochlorideNS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM; decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.); decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD). |
| Name | NS-3-008 |
|---|
| Description | NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM; decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.); decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD). |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.25 μM (G0s2)[1] |
| In Vitro | NS-3-008 binds to Hsd17b4; knockdown of Hsd17b4 decreased G0s2 mRNA levels, whereas overexpression of Hsd17b4 induced G0s2 mRNA expression. The inhibitory effects of NS-3-008 are blocked by knockdown of Hsd17b4 or deletion of the Stat5 binding site in the G0s2 promoter. NS-3-008 decreases the nuclear phosphorylation of Stat5[1]. |
| In Vivo | NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008[1]. |
| References |
| Molecular Formula | C14H24ClN3 |
|---|---|
| Molecular Weight | 269.817 |
| Storage condition | 2-8℃ |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: NS-3-008 hydrochloride
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: NS-3-008 HCl
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: NS-3-008 HCl
- Price: $500.0/100mg $900.0/250mg $1700.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
Get all suppliers and price by the below link: