FM-479
Modify Date: 2024-01-14 02:45:23
FM-479 structure
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Common Name | FM-479 | ||
|---|---|---|---|---|
| CAS Number | 2226521-64-6 | Molecular Weight | 442.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H26N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FM-479FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. |
| Name | FM-479 |
|---|
| Description | FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. |
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| Related Catalog | |
| Target |
JAK3 |
| In Vitro | FM-479 is the inactive control of FM-381, the concentration used in assays is similar[1]. |
| References |
| Molecular Formula | C25H26N6O2 |
|---|---|
| Molecular Weight | 442.51 |