VH 032, phenol

Modify Date: 2024-01-14 09:03:07

VH 032, phenol structure	Common Name	VH 032, phenol
	CAS Number	2244684-42-0	Molecular Weight	488.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₂N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VH 032, phenol

VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	VH032-OH

Description	VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	VHL
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017;8(1):830. Published 2017 Oct 10.

Molecular Formula	C₂₄H₃₂N₄O₅S
Molecular Weight	488.60

Hazard Codes	Xi

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