VH 032, phenol

Modify Date: 2024-01-14 09:03:07

VH 032, phenol Structure
VH 032, phenol structure
Common Name VH 032, phenol
CAS Number 2244684-42-0 Molecular Weight 488.60
Density N/A Boiling Point N/A
Molecular Formula C24H32N4O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VH 032, phenol


VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

 Names

Name VH032-OH

 VH 032, phenol Biological Activity

Description VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog
Target

VHL

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017;8(1):830. Published 2017 Oct 10.

 Chemical & Physical Properties

Molecular Formula C24H32N4O5S
Molecular Weight 488.60

 Safety Information

Hazard Codes Xi