Vardenafil dihydrochloride
Vardenafil dihydrochloride structure
|
Common Name | Vardenafil dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 224789-15-5 | Molecular Weight | 561.525 | |
| Density | N/A | Boiling Point | 692.2ºC at 760mmHg | |
| Molecular Formula | C23H34Cl2N6O4S | Melting Point | 214-216°C | |
| MSDS | N/A | Flash Point | 372.5ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of Vardenafil dihydrochlorideVardenafil, also known as BAY 38-9456, is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's. |
| Name | Vardenafil Dihydrochloride Salt |
|---|---|
| Synonym | More Synonyms |
| Boiling Point | 692.2ºC at 760mmHg |
|---|---|
| Melting Point | 214-216°C |
| Molecular Formula | C23H34Cl2N6O4S |
| Molecular Weight | 561.525 |
| Flash Point | 372.5ºC |
| Exact Mass | 560.173950 |
| PSA | 253.41000 |
| LogP | 1.77850 |
| Vapour Pressure | 5.17E-19mmHg at 25°C |
| Storage condition | Refrigerator |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
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Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor Vardenafil.
Respir. Physiol. Neurobiol. 186(1) , 61-4, (2013) Vardenafil, a phosphodiesterase-5 inhibitor, is approved for the therapy of erectile dysfunction. However, in contrast to Sildenafil and Tadalafil, little is known about its effects on pulmonary hyper... |
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SOP conservative (medical and mechanical) treatment of erectile dysfunction.
J. Sex. Med. 10(1) , 130-71, (2013) Erectile dysfunction (ED) is the most frequently treated male sexual dysfunction worldwide. ED is a chronic condition that exerts a negative impact on male self-esteem and nearly all life domains incl... |
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High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension.
Eur. J. Clin. Pharmacol. 69(2) , 197-207, (2013) To evaluate the pharmacokinetic parameters of a single oral dose of vardenafil in patients with pulmonary hypertension (PH).Sixteen patients with PH received vardenafil in single oral doses (20, 10 or... |
| MFCD06797950 |
| Vardenafil dihydrochloride |
| EINECS 200-659-6 |