AHR antagonist 5

Modify Date: 2024-01-12 21:44:25

AHR antagonist 5 structure	Common Name	AHR antagonist 5
	CAS Number	2247953-39-3	Molecular Weight	550.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₇Cl₃FN₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AHR antagonist 5

AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1[1].

Name	AHR antagonist 5

Description	AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor
In Vivo	Tumor growth inhibition is statistically significant with AHR antagonist 5 as single. AHR antagonist 5 (10 mg/kg; p.o.; every day for 3 weeks) combination with anti-PD-1 significantly inhibited tumor growth inhibition compared to the anti-PD-1 alone[1]. Animal Model: Balb/c Mice (Mouse Colorectal Cancer Model CT26)[1] Dosage: 10 mg/kg (combination with anti-PD-1) Administration: P.o.; every day for 3 weeks Result: Significantly inhibited tumor growth inhibition.
References	[1]. Alfredo C. Castro, et al. Indole ahr inhibitors and uses thereof. WO2018195397A2.

Molecular Formula	C₂₅H₂₇Cl₃FN₇
Molecular Weight	550.89

AHR antagonist 5

Use of AHR antagonist 5

Names

AHR antagonist 5 Biological Activity

Chemical & Physical Properties