CCR2 antagonist 5
Modify Date: 2024-01-10 12:55:49
CCR2 antagonist 5 structure
|
Common Name | CCR2 antagonist 5 | ||
|---|---|---|---|---|
| CAS Number | 1228650-83-6 | Molecular Weight | 482.51900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H25F3N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CCR2 antagonist 5CCR2 antagonist 5 is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). CCR2 antagonist 5 displays a Ki of 9.6 µM for mCCR2 binding. CCR2 antagonist 5 can be used in the research of inflammatory disease[1]. |
| Name | N-[2-[[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | CCR2 antagonist 5 is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). CCR2 antagonist 5 displays a Ki of 9.6 µM for mCCR2 binding. CCR2 antagonist 5 can be used in the research of inflammatory disease[1]. |
|---|---|
| Related Catalog | |
| Target |
hCCR2:37 nM (IC50) mCCR2:9.6 μM (Ki) |
| In Vivo | CCR2 antagonist 5 (compound 8d) dose-dependently inhibits the influx of leukocytes, monocytes/macrophages and T-lymphocytes into the peritoneal cavity with an ED50 of 3 mg/kg p.o. bid in a thioglycollate-induced peritonitis (TG) model[1]. CCR2 antagonist 5 has good CV safety profile. It does not induce dose-dependent or notable effects on most cardiohemodynamic, functional respiratory and electrophysiological parameters up to 10 mg/kg (i.v.) with plasma level at 70 µM in an anesthetized dog[1]. CCR2 antagonist 5 has amendable oral bioavailability in dogs and primates. Pharmacokinetic parameters (p.o.)[1]: Species Dose (mg/kg) Cmax (ng/mL) AUClast (h*ng/mL) Oral bioavailability (%) dogs 6.7 1617 5887 70.2 non-human primates 7.2 740 3061 25.4 mice 10 74 204 19 rats 10 100 416 15.3 |
| References |
| Molecular Formula | C22H25F3N4O3S |
|---|---|
| Molecular Weight | 482.51900 |
| Exact Mass | 482.16000 |
| PSA | 129.78000 |
| LogP | 3.87550 |
| Benzamide,N-(2-((1-(trans-4-hydroxy-4-(5-thiazolyl)cyclohexyl)-3-azetidinyl)amino)-2-oxoethyl)-3-(trifluoromethyl) |
| UNII-0OJB0LES1A |