Girinimbine
Modify Date: 2025-08-25 11:09:39
Girinimbine structure
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Common Name | Girinimbine | ||
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| CAS Number | 23095-44-5 | Molecular Weight | 263.33400 | |
| Density | 1.187g/cm3 | Boiling Point | 450ºC at 760mmHg | |
| Molecular Formula | C18H17NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 161.5ºC | |
Use of GirinimbineGirinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3]. |
| Name | girinimbine |
|---|---|
| Synonym | More Synonyms |
| Description | Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3]. |
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| Related Catalog | |
| In Vitro | Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells[1]. Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells[1].HepG2 cells[1]. Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest[1]. Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 µg/mL[3]. Cell Viability Assay[1] Cell Line: HepG2 cells Concentration: 1 µM, 10 µM, 50 µM, 100 µM, 200 µM Incubation Time: 24 h, 48 h and 72 h Result: Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: HepG2 cells Concentration: 56 µM Incubation Time: 24 h, 48 h Result: Showed typical morphological features of apoptosis. Cell Cycle Analysis[1] Cell Line: HepG2 cells Concentration: 56 µM Incubation Time: 12 h, 24 h, 48 h Result: Induced G0/G1-phase arrest in HepG2 cells. |
| In Vivo | Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid[2]. In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos[2]. Animal Model: Male ICR mice (25-35 g) treated with carrageenan[2] Dosage: 10 mg/kg, 30 mg/kg, and 100 mg/kg Administration: Orally gavage; once Result: Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid. |
| References |
| Density | 1.187g/cm3 |
|---|---|
| Boiling Point | 450ºC at 760mmHg |
| Molecular Formula | C18H17NO |
| Molecular Weight | 263.33400 |
| Flash Point | 161.5ºC |
| Exact Mass | 263.13100 |
| PSA | 25.02000 |
| LogP | 4.81370 |
| Vapour Pressure | 7.27E-08mmHg at 25°C |
| Index of Refraction | 1.68 |
| InChIKey | GAEQWKVGMHUUKO-UHFFFAOYSA-N |
| SMILES | Cc1cc2c([nH]c3ccccc32)c2c1OC(C)(C)C=C2 |
| HS Code | 2934999090 |
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CAS#:24224-30-4
CAS#:107-86-8
CAS#:5428-54-6
CAS#:16452-01-0
CAS#:1072127-10-6
CAS#:24224-28-0
CAS#:99-55-8| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: CHOP dose-response primary assay
Source: Emory University Molecular Libraries Screening Center
Target: DNA damage-inducible transcript 3 protein [Mus musculus]
External Id: CHOP dose-response primary assay
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|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: Anticancer activity against human HeLa cells by MTT assay
Source: ChEMBL
Target: HeLa
External Id: CHEMBL4679148
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Name: Anticancer activity against human KETR3 cells by MTT assay
Source: ChEMBL
Target: KETR3
External Id: CHEMBL4679147
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Name: Anticancer activity against human A431 cells by MTT assay
Source: ChEMBL
Target: A-431
External Id: CHEMBL4679150
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Name: Anticancer activity against human A2780 cells by MTT assay
Source: ChEMBL
Target: A2780
External Id: CHEMBL4679149
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| grinimibine |
| Cririnimhin |
| girinbimbine |