Girinimbine
Girinimbine structure
|
Common Name | Girinimbine | ||
|---|---|---|---|---|
| CAS Number | 23095-44-5 | Molecular Weight | 263.33400 | |
| Density | 1.187g/cm3 | Boiling Point | 450ºC at 760mmHg | |
| Molecular Formula | C18H17NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 161.5ºC | |
Use of GirinimbineGirinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3]. |
Summary: Girinimbine, Chinese name: 吉九里香碱, CAS number: 23095-44-5, molecular formula: C18H17NO, molecular weight: 263.33400. Appearance: powder, boiling point: 450ºC, density: 1.187g/cm3. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | girinimbine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells[1]. Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells[1].HepG2 cells[1]. Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest[1]. Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 µg/mL[3]. Cell Viability Assay[1] Cell Line: HepG2 cells Concentration: 1 µM, 10 µM, 50 µM, 100 µM, 200 µM Incubation Time: 24 h, 48 h and 72 h Result: Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: HepG2 cells Concentration: 56 µM Incubation Time: 24 h, 48 h Result: Showed typical morphological features of apoptosis. Cell Cycle Analysis[1] Cell Line: HepG2 cells Concentration: 56 µM Incubation Time: 12 h, 24 h, 48 h Result: Induced G0/G1-phase arrest in HepG2 cells. |
| In Vivo | Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid[2]. In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos[2]. Animal Model: Male ICR mice (25-35 g) treated with carrageenan[2] Dosage: 10 mg/kg, 30 mg/kg, and 100 mg/kg Administration: Orally gavage; once Result: Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.187g/cm3 |
|---|---|
| Boiling Point | 450ºC at 760mmHg |
| Molecular Formula | C18H17NO |
| Molecular Weight | 263.33400 |
| Flash Point | 161.5ºC |
| Exact Mass | 263.13100 |
| PSA | 25.02000 |
| LogP | 4.81370 |
| Vapour Pressure | 7.27E-08mmHg at 25°C |
| Index of Refraction | 1.68 |
| InChIKey | GAEQWKVGMHUUKO-UHFFFAOYSA-N |
| SMILES | Cc1cc2c([nH]c3ccccc32)c2c1OC(C)(C)C=C2 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2934999090 |
|---|
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 0 | |
CAS#:24224-30-4
CAS#:107-86-8
CAS#:5428-54-6
CAS#:16452-01-0
CAS#:1072127-10-6
CAS#:24224-28-0
CAS#:99-55-8This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
|
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
|
|
Name: CHOP dose-response primary assay
Source: Emory University Molecular Libraries Screening Center
Target: DNA damage-inducible transcript 3 protein [Mus musculus]
External Id: CHOP dose-response primary assay
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
|
|
Name: Anticancer activity against human HeLa cells by MTT assay
Source: ChEMBL
Target: HeLa
External Id: CHEMBL4679148
|
|
Name: Anticancer activity against human KETR3 cells by MTT assay
Source: ChEMBL
Target: KETR3
External Id: CHEMBL4679147
|
|
Name: Anticancer activity against human A431 cells by MTT assay
Source: ChEMBL
Target: A-431
External Id: CHEMBL4679150
|
|
Name: Anticancer activity against human A2780 cells by MTT assay
Source: ChEMBL
Target: A2780
External Id: CHEMBL4679149
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| grinimibine |
| Cririnimhin |
| girinbimbine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of girinimbine? |
| A: SMILES notation of girinimbine is Cc1cc2c([nH]c3ccccc32)c2c1OC(C)(C)C=C2. |
| Q: What is the molecular formula of girinimbine? |
| A: Molecular formula of girinimbine is C18H17NO. |
| Q: What are the upstream materials of girinimbine? |
| A: Related upstream materials(CAS) of girinimbine: 24224-30-4;107-86-8;5428-54-6;16452-01-0;1072127-10-6;24224-28-0;99-55-8. |
| Q: What is the polar surface area (PSA) of girinimbine? |
| A: Polar surface area (PSA) of girinimbine is 25.02000. |
| Q: What is the CAS number of girinimbine? |
| A: CAS number of girinimbine is 23095-44-5. |
| Q: What is the boiling point of girinimbine? |
| A: Boiling point of girinimbine is 450ºC at 760mmHg. |
| Q: What are the uses of girinimbine? |
| A: Main uses of girinimbine: Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3]. |
| Q: What is the LogP of girinimbine? |
| A: LogP of girinimbine is 4.81370. |
| Q: What is the English name of girinimbine? |
| A: The English name of girinimbine is girinimbine. |
| Q: What English synonyms does girinimbine have? |
| A: English synonyms of girinimbine: grinimibine, Cririnimhin, girinbimbine. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |