UK 356618
Modify Date: 2024-02-02 19:35:39
UK 356618 structure
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Common Name | UK 356618 | ||
|---|---|---|---|---|
| CAS Number | 230961-08-7 | Molecular Weight | 557.72300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H43N3O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of UK 356618UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM. UK 356618 is >140-fold less potent against MMP-1 (IC50 of 51,000 nM), MMP-2 (IC50 of 1790 nM), MMP-9 (IC50 of 840 nM) and MMP-14 (IC50 of 1900 nM) compared with MMP-3[1]. |
| Name | (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-N'-hydroxy-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide |
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| Synonym | More Synonyms |
| Description | UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM. UK 356618 is >140-fold less potent against MMP-1 (IC50 of 51,000 nM), MMP-2 (IC50 of 1790 nM), MMP-9 (IC50 of 840 nM) and MMP-14 (IC50 of 1900 nM) compared with MMP-3[1]. |
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| Related Catalog | |
| Target |
MMP-3:5.9 nM (IC50) |
| References |
| Molecular Formula | C34H43N3O4 |
|---|---|
| Molecular Weight | 557.72300 |
| Exact Mass | 557.32500 |
| PSA | 118.00000 |
| LogP | 8.42560 |
| (2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide |
| (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide |
| UK-356,618 |