4-Epitetracycline hydrochloride structure
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Common Name | 4-Epitetracycline hydrochloride | ||
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CAS Number | 23313-80-6 | Molecular Weight | 480.896 | |
Density | N/A | Boiling Point | 682.8ºC at 760mmHg | |
Molecular Formula | C22H25ClN2O8 | Melting Point | 217ºC | |
MSDS | Chinese USA | Flash Point | 366.7ºC | |
Symbol |
GHS07, GHS08 |
Signal Word | Warning |
Use of 4-Epitetracycline hydrochloride4-Epitetracycline hydrochloride is an epimer of the antibiotic tetracycline. Epimers of tetracycline form without catalysis and are considered degradation products. 4-Epitetracycline hydrochloride has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals. |
Name | (4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide,hydrochloride |
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Synonym | More Synonyms |
Description | 4-Epitetracycline hydrochloride is an epimer of the antibiotic tetracycline. Epimers of tetracycline form without catalysis and are considered degradation products. 4-Epitetracycline hydrochloride has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals. |
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Boiling Point | 682.8ºC at 760mmHg |
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Melting Point | 217ºC |
Molecular Formula | C22H25ClN2O8 |
Molecular Weight | 480.896 |
Flash Point | 366.7ºC |
Exact Mass | 480.129944 |
PSA | 181.62000 |
LogP | 1.28790 |
Appearance of Characters | Fine Crystalline Powder | Yellow |
Index of Refraction | 1.74 |
Storage condition | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
Synonym:Quatrimycin Hydrochloride Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 63 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Possible risk of harm to the unborn child.Light sensitive.Moisture sensitive.Air sensitive.The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. May cause liver and kidney damage. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. May cause liver and kidney damage. The toxicological properties of this substance have not been fully investigated. Chronic: May cause liver and kidney damage. May cause reproductive and fetal effects. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Do NOT get water inside containers. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere. Do not get water inside containers. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Handle under an inert atmosphere. Store protected from air. Do not allow contact with water. Keep from contact with moist air and steam. Storage: Do not store in direct sunlight. Store in a tightly closed container. Keep under a nitrogen blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store protected from moisture. Store protected from light. Store under an inert atmosphere. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 23313-80-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: yellow Odor: none reported pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 217 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: > 217 deg C Solubility in water: in water: 1:10 m/v Specific Gravity/Density: Molecular Formula: C22H24N2O8.HCl Molecular Weight: 480.89 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, light, moisture, exposure to air, exposure to moist air or water. Incompatibilities with Other Materials: Moisture, air. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 23313-80-6: QJ1898250 LD50/LC50: Not available. Carcinogenicity: 4-Epitetracycline Hydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 63 Possible risk of harm to the unborn child. Safety Phrases: S 28A After contact with skin, wash immediately with plenty of water. S 36/37 Wear suitable protective clothing and gloves. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 23313-80-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 23313-80-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 23313-80-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07, GHS08 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335-H361 |
Precautionary Statements | P280-P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | Xn: Harmful; |
Risk Phrases | 63-36-36/37/38 |
Safety Phrases | 36/37/39-26-36 |
RIDADR | NONH for all modes of transport |
RTECS | QJ1898250 |
HS Code | 29413000 |
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4-epi-Tetracycline hydrochloride |
4-Epitetracycline hydrochloride |
4-Epitetracycline hydrochloride,‘can be used as a secondary standard‘ |
2,2,2,2-Propanetetracarbonitrile |
4-epi-TetracyclineHydrochloride |
(4R,4aS,5aS,6S,12aS)-4-(Dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide hydrochloride (1:1) |
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4R,4aS,5aS,6S,12aS)-, hydrochloride (1:1) |
MFCD00085371 |
Epitetracycline hydrochloride |
Tetracyanomethane |