PI3K/mTOR Inhibitor-13 sodium
Modify Date: 2024-04-03 10:01:17
PI3K/mTOR Inhibitor-13 sodium structure
|
Common Name | PI3K/mTOR Inhibitor-13 sodium | ||
|---|---|---|---|---|
| CAS Number | 2361009-23-4 | Molecular Weight | 464.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H13F2N5NaO3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI3K/mTOR Inhibitor-13 sodiumPI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF)[1][2]. |
| Name | PI3K/mTOR Inhibitor-13 sodium |
|---|
| Description | PI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF)[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | PI3K/mTOR Inhibitor-13 sodium (Compound A) (0-2 µM；48 h) 以剂量依赖性方式抑制 HFL1 细胞的增值[1]。 Cell Proliferation Assay[1] Cell Line: HFL1 cells. Concentration: 0, 0.03125, 0.0125, 0.025, 0.05, 0.0625, 0.1, 0.125, 0.2, 0.25, 0.4, 0.5, 1 and 2 µM. Incubation Time: 48 h. Result: Showed inhibitory for HFL1 cells. Western Blot Analysis[1] Cell Line: HFL1 cells. Concentration: 200 nM. Incubation Time: 48 h. Result: Increased the expression of α-SMA/Tubulin. |
| In Vivo | PI3K/mTOR Inhibitor-13 sodium 的药代动力学 (PK) 参数[2] Species Administration manner Dose (mg/kg) T1/2 (h) AUClast (ng•h/mL) Cl/F (L/h/kg) Vss (L/kg) F (%) Rat Intravenous injection 2 2.77 7069 0.29 0.85 94.75 Mice Intravenous injection 1 5.45 57059 0.02 0.13 79.3 Dog Intravenous injection 1 0.67 3672 0.27 0.23 108.5 Monkey Intravenous injection 1 9.70 5978 0.16 0.92 59.8 |
| References |
| Molecular Formula | C20H13F2N5NaO3S |
|---|---|
| Molecular Weight | 464.40 |