(S,R,S)-AHPC-C1-NH2 hydrochloride

Modify Date: 2024-01-10 12:28:24

(S,R,S)-AHPC-C1-NH2 hydrochloride Structure
(S,R,S)-AHPC-C1-NH2 hydrochloride structure
Common Name (S,R,S)-AHPC-C1-NH2 hydrochloride
CAS Number 2361120-26-3 Molecular Weight 524.08
Density N/A Boiling Point N/A
Molecular Formula C24H34ClN5O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (S,R,S)-AHPC-C1-NH2 hydrochloride


(S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].

 Names

Name (S,R,S)-AHPC-C1-NH2 hydrochloride

 (S,R,S)-AHPC-C1-NH2 hydrochloride Biological Activity

Description (S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

VHL

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Molecular Formula C24H34ClN5O4S
Molecular Weight 524.08

 Safety Information

Hazard Codes Xi
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