FKBP12 PROTAC RC32

Modify Date: 2024-01-14 17:29:08

FKBP12 PROTAC RC32 structure	Common Name	FKBP12 PROTAC RC32
	CAS Number	2375555-66-9	Molecular Weight	1426.69
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇₅H₁₀₇N₇O₂₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FKBP12 PROTAC RC32

FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an E3 ubiquitin ligase (Pomalidomide; HY-10984)[1].

Name	FKBP12 PROTAC RC32

Description	FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an E3 ubiquitin ligase (Pomalidomide; HY-10984)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	Cereblon
In Vitro	FKBP12 PROTAC RC32 (RC32; 0.1-1000 nM; for 12 hours) results in 50% protein degradation (DC50) of ~0.3 nM after only 12 hours of treatment[1]. Western Blot Analysis[1] Cell Line: Jurkat cells Concentration: 0.1, 1, 10, 100, 1000 nM Incubation Time: For 12 hours Result: Resulted in 50% protein degradation (DC50) of ~0.3 nM after only 12 h of treatment.
In Vivo	RC32 (RC32; i.p.; 30 mg/kg; twice a day; 1 day) degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice[1]. RC32 (orally; 60 mg/kg; twice a day; for 1 day) significantly degrades FKBP12 in mice[1]. RC32 (i.p.; 8 mg/kg; twice a day; for 2 days) efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20 kg) [1]. RC32 (i.p.; 8 mg/kg; twice a day; for 3 days) efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys[1]. Animal Model: Male and female mice[1] Dosage: 30 mg/kg Administration: IP; twice a day; 1 day Result: Degraded the FKBP12 protein in most of the organs of treated mice after only 1 day of treatment.
References	[1]. A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10.

Molecular Formula	C₇₅H₁₀₇N₇O₂₀
Molecular Weight	1426.69
Storage condition	-20°C

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FKBP12 PROTAC RC32
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