FKBP12 PROTAC dTAG-13
Modify Date: 2024-01-15 19:17:19
FKBP12 PROTAC dTAG-13 structure
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Common Name | FKBP12 PROTAC dTAG-13 | ||
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| CAS Number | 2064175-41-1 | Molecular Weight | 1049.168 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1134.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C57H68N4O15 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 639.6±34.3 °C | |
Use of FKBP12 PROTAC dTAG-13FKBP12 PROTAC dTAG-13 (dTAG-13) is an in vivo-active heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells; causes rapid degradation of nuclear and cytoplasmic FKBP12F36V fusion chimeras, and an unexpected superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation, characterize immediate effects of KRASG12V loss on proteomic signaling, and demonstrate rapid degradation in vivo. |
| Name | (1R)-3-(3,4-Dimethoxyphenyl)-1-(2-{2-[(6-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}hexyl)amino]-2-oxoethoxy}phenyl)propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]-2-piperidinecarboxylate |
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| Synonym | More Synonyms |
| Description | FKBP12 PROTAC dTAG-13 (dTAG-13) is an in vivo-active heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells; causes rapid degradation of nuclear and cytoplasmic FKBP12F36V fusion chimeras, and an unexpected superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation, characterize immediate effects of KRASG12V loss on proteomic signaling, and demonstrate rapid degradation in vivo. |
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| References | References 1. Nabet B, et al. Nat Chem Biol. 2018 May;14(5):431-441. View Related Products by Target PROTAC |
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 1134.0±65.0 °C at 760 mmHg |
| Molecular Formula | C57H68N4O15 |
| Molecular Weight | 1049.168 |
| Flash Point | 639.6±34.3 °C |
| Exact Mass | 1048.468140 |
| LogP | 6.98 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.581 |
| (1R)-3-(3,4-Dimethoxyphenyl)-1-(2-{2-[(6-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}hexyl)amino]-2-oxoethoxy}phenyl)propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]-2-piperidinecarboxylate |
| 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester, (2S)- |