ITK inhibitor 6
Modify Date: 2025-08-22 12:22:33
ITK inhibitor 6 structure
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Common Name | ITK inhibitor 6 | ||
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| CAS Number | 2404604-06-2 | Molecular Weight | 486.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H24F2N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ITK inhibitor 6ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities[1]. |
| Name | ITK inhibitor 6 |
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| Description | ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities[1]. |
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| Related Catalog | |
| Target |
IC50: 4 nM (ITK); 133 nM (BTK), 320 nM (JAK3), 2360 nM (EGFR), 155 nM (LCK)[1] |
| In Vitro | ITK inhibitor 6 (compound 43) shows antiproliferative activities with GI50s of 5.1, 3.7, 3.4, 5.4, 19 µM for Jurkat, Molt-4, CCRF-CEM, H9, HEK 293 T cells, respectively[1]. ITK inhibitor 6 docks into the ATP-binding site of ITK and BTK[1]. |
| References |
| Molecular Formula | C28H24F2N4O2 |
|---|---|
| Molecular Weight | 486.51 |