JAK/HDAC-IN-1

Modify Date: 2024-01-22 10:23:56

JAK/HDAC-IN-1 structure	Common Name	JAK/HDAC-IN-1
	CAS Number	2284621-75-4	Molecular Weight	450.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₁Cl₂N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JAK/HDAC-IN-1

JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively[1].

Name	JAK/HDAC-IN-1

Description	JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	JAK2:4 nM (IC50) JAK1:4.8 nM (IC50) JAK3:7.4 nM (IC50) Tyk2:49 nM (IC50) HDAC:2 nM (IC50) HDAC2:14 nM (IC50) HDAC6:120 nM (IC50) HDAC8:2470 nM (IC50)
In Vitro	JAK/HDAC-IN-1 (Compound 8m) exhibits IC50s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively[1].
References	[1]. Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.

Molecular Formula	C₁₉H₂₁Cl₂N₇O₂
Molecular Weight	450.32

DC Chemicals Limited
China
Product Name: JAK/HDAC-IN-1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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