Snail/HDAC-IN-1
Modify Date: 2024-01-04 21:07:50
Snail/HDAC-IN-1 structure
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Common Name | Snail/HDAC-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2415281-52-4 | Molecular Weight | 488.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H21FN8OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Snail/HDAC-IN-1Snail/HDAC-IN-1 is a potent Snail/HDAC dual target inhibitor. Snail/HDAC-IN-1 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis[1]. |
| Name | Snail/HDAC-IN-1 |
|---|
| Description | Snail/HDAC-IN-1 is a potent Snail/HDAC dual target inhibitor. Snail/HDAC-IN-1 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis[1]. |
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| Related Catalog | |
| Target |
HDAC1:0.405 μM (IC50) Snail:0.18 μM (Kd) |
| In Vitro | Snail/HDAC-IN-1 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751 μM. Snail/HDAC-IN-1 shows a good inhibitory effect on NCI–H522 (GI50=0.0488 μM), MDA-MB-435 (GI50=0.0361 μM), and MCF7 (GI50=0.0518 μM)[1]. |
| References |
| Molecular Formula | C24H21FN8OS |
|---|---|
| Molecular Weight | 488.54 |