DDR1-IN-5

Modify Date: 2024-01-10 18:45:59

DDR1-IN-5 structure	Common Name	DDR1-IN-5
	CAS Number	2416022-90-5	Molecular Weight	434.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₃F₃N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DDR1-IN-5

DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1].

Name	DDR1-IN-5

Description	DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Discoidin Domain Receptor
Target	DDR1:7.36 nM (IC50)
In Vitro	DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=62 nM)[1]. DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC50>40 μM)[1].
References	[1]. Aleksandr M. Aliper, et al. Kinase inhibitors. WO2020079652A1.

Molecular Formula	C₂₂H₁₃F₃N₆O
Molecular Weight	434.37

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DDR1-IN-5
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Purity: 99.0%
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