epiyangambin

Modify Date: 2024-01-12 18:46:47

epiyangambin Structure
epiyangambin structure
Common Name epiyangambin
CAS Number 24192-64-1 Molecular Weight 446.49
Density 1.183g/cm3 Boiling Point 556.1ºC at 760 mmHg
Molecular Formula C24H30O8 Melting Point 112-114℃
MSDS N/A Flash Point 221.1ºC

 Use of epiyangambin


Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells)[1][2].

 Names

Name 3,6-bis(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan
Synonym More Synonyms

 epiyangambin Biological Activity

Description Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells)[1][2].
Related Catalog
In Vitro Epiyangambin (0-25 µM; 24 h) 以剂量依赖性方式抑制 SW480 细胞的生长[1]。 Cell Viability Assay[1] Cell Line: SW480 cells Concentration: 0-25 µM Incubation Time: 24 h Result: Caused reductions in cell number in a dose-dependent manner.
In Vivo Epiyangambin (20 mg/kg) 显著抑制血小板激活因子受体 (PAF) 诱导的大鼠血小板减少症[2]。
References

[1]. Hausott B, et al. Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. J Cancer Res Clin Oncol. 2003 Oct;129(10):569-76.  

[2]. Castro-Faria-Neto HC, et al. Pharmacological profile of epiyangambin: a furofuran lignan with PAF antagonist activity. J Lipid Mediat. 1993 May;7(1):1-9.  

 Chemical & Physical Properties

Density 1.183g/cm3
Boiling Point 556.1ºC at 760 mmHg
Melting Point 112-114℃
Molecular Formula C24H30O8
Molecular Weight 446.49
Flash Point 221.1ºC
Exact Mass 446.19400
PSA 73.84000
LogP 3.81340
Vapour Pressure 7.78E-12mmHg at 25°C
Index of Refraction 1.537

 Safety Information

Hazard Codes Xi
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

syringaresinol dimethyl ether
lirioresinol B dimethyl ether
epiyangambin
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