HDAC6 degrader-1

Modify Date: 2024-01-14 20:24:15

HDAC6 degrader-1 Structure
HDAC6 degrader-1 structure
Common Name HDAC6 degrader-1
CAS Number 2439058-23-6 Molecular Weight 795.84
Density N/A Boiling Point N/A
Molecular Formula C40H45N9O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HDAC6 degrader-1


HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation[1].

 Names

Name HDAC6 degrader-1

 HDAC6 degrader-1 Biological Activity

Description HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation[1].
Related Catalog
References

[1]. An Z, et al. Developing potent PROTACs tools for selective degradation of HDAC6 protein [published correction appears in Protein Cell. 2019 Feb 22;:]. Protein Cell. 2019;10(8):606-609.

 Chemical & Physical Properties

Molecular Formula C40H45N9O9
Molecular Weight 795.84
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