Anticancer agent 76

Modify Date: 2024-01-12 17:42:56

Anticancer agent 76 Structure
Anticancer agent 76 structure
Common Name Anticancer agent 76
CAS Number 2448091-11-8 Molecular Weight 543.67
Density N/A Boiling Point N/A
Molecular Formula C32H33NO5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Anticancer agent 76


Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis[1].

 Names

Name Anticancer agent 76

 Anticancer agent 76 Biological Activity

Description Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis[1].
Related Catalog
In Vitro Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells[1]. Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells [1]. Cell Proliferation Assay[1] Cell Line: A549 and H460 Concentration: 0, 10, 20, 40, 60 and 80 μM Incubation Time: 24 h Result: Inhibited the proliferation with IC50 values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively. Cell Cycle Analysis[1] Cell Line: H460 Concentration: 40 μM Incubation Time: 24 h Result: Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1. Apoptosis Analysis[1] Cell Line: A549 and H460 Concentration: 20 μM and 40 μM Incubation Time: 24 h Result: Induced apoptosis. Western Blot Analysis[1] Cell Line: H460 cell Concentration: 40 μM Incubation Time: 24 h Result: Down-regulated mRNA of TOP2B, TOP3B and c-Myc.
References

[1]. Chen J, et al. CT2-3, a novel magnolol analogue suppresses NSCLC cells through triggering cell cycle arrest and apoptosis. Bioorg Med Chem. 2020 Mar 15;28(6):115352.

 Chemical & Physical Properties

Molecular Formula C32H33NO5S
Molecular Weight 543.67
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