Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Anticancer agent 43
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Purity: 98.88%
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2470015-35-9

2470015-35-9 structure

2470015-35-9 structure

Name: Anticancer agent 43
Chemical Name: Anticancer agent 43
CAS Number: 2470015-35-9
Molecular Formula: C₁₄H₉FN₂O₃S₂
Molecular Weight: 336.36
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-05-21 17:04:01
Modify Date: 2024-01-09 15:52:49
Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage[1].

Name	Anticancer agent 43

Description	Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	Caspase 3 PARP1 Bax
In Vitro	Anticancer agent 43 (compound 3a) shows selectivity toward human tumor cells (SI50=28.94)[1]. Anticancer agent 43 (45 µM, 24 h) induces apoptosis via caspase 3, PARP1 and Bax dependent pathways in HepG2 cells[1]. Anticancer agent 43 (45 µM, 24 h) shows no effect on the transition of G1/S phases in HepG2 cells[1]. Anticancer agent 43 (0.7, 45, 55 µM) induces DNA damage in HCT116 cells (Tail DNA=16.1%, OTM=3.7), MCF-7 cells, HepG2 cells (Tail DNA=26.2%, OTM=13.2), Balb/c 3T3 cells (Tail DNA = 8.4%, OTM = 3.5)[1]. Cell Cytotoxicity Assay[1] Cell Line: HepG2, MCF-7, HCT116, HeLa, A549, WM793, THP-1, HaCaT, Balb/c3T3 cells Concentration: 0, 1, 10, 100 µM Incubation Time: 72 h Result: Showed cytotoxic action with GI50s of 12.1, 0.7, 0.8, 49.3, 9.7 µM for for HepG2, MCF-7, HCT116, HeLa, A549 cells, low toxicity towards WM793, THP-1, HaCaT, Balb/c 3T3 cells with GI50s of 80.4, 62.4,98.3,40.8 µM , respectively. Apoptosis Analysis[1] Cell Line: HepG2 cells Concentration: 45 µM Incubation Time: 24 h Result: Induced apoptosis in HepG2 cells via caspase 3, PARP1 and Bax dependent pathways. Western Blot Analysis[1] Cell Line: HCT116, MCF-7 cells Concentration: 0.7 µM Incubation Time: 24 h Result: Decreased the expression of Cdk2 protein in HCT116 and MCF-7 cells. Cell Cycle Analysis[1] Cell Line: HepG2 cells Concentration: 45 µM Incubation Time: 24 h Result: Showed no effect on the transition of G1/S phases in HepG2 cells.
References	[1]. Kryshchyshyn-Dylevych A, et al. Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential. Bioorg Med Chem. 2021; 50:116453.

Molecular Formula	C₁₄H₉FN₂O₃S₂
Molecular Weight	336.36