OM99-2 TFA

Modify Date: 2024-01-02 09:16:14

OM99-2 TFA structure	Common Name	OM99-2 TFA
	CAS Number	2504147-81-1	Molecular Weight	1007.02
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₃H₆₅F₃N₈O₁₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of OM99-2 TFA

OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor[2], has the potential for the research of the Alzheimer's disease[3].

Name	OM99-2 TFA

Description	OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor[2], has the potential for the research of the Alzheimer's disease[3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	Ki: 9.58 nM (memapsin 2)
In Vitro	Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4].
References	[1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422.

Molecular Formula	C₄₃H₆₅F₃N₈O₁₆
Molecular Weight	1007.02

Hazard Codes	Xi

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OM99-2 TFA

Use of OM99-2 TFA

Names

OM99-2 TFA Biological Activity

Chemical & Physical Properties

Safety Information

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.