Tubulin polymerization-IN-30

Modify Date: 2024-01-17 18:16:57

Tubulin polymerization-IN-30 Structure
Tubulin polymerization-IN-30 structure
Common Name Tubulin polymerization-IN-30
CAS Number 2521560-46-1 Molecular Weight 407.47
Density N/A Boiling Point N/A
Molecular Formula C22H25N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tubulin polymerization-IN-30


Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC50 values of 2.16, 2.21, and 0.403 μM[1].

 Names

Name Tubulin polymerization-IN-30

 Tubulin polymerization-IN-30 Biological Activity

Description Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC50 values of 2.16, 2.21, and 0.403 μM[1].
Related Catalog
References

[1]. Wang C, et al. Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles. Bioorg Chem. 2020 Nov;104:103909.

 Chemical & Physical Properties

Molecular Formula C22H25N5O3
Molecular Weight 407.47
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