UC-764864
Modify Date: 2024-04-03 10:26:03
UC-764864 structure
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Common Name | UC-764864 | ||
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| CAS Number | 2566480-62-2 | Molecular Weight | 322.426 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H18N2Os | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UC-764864UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro. |
| Name | UC-764864 |
|---|
| Description | UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro. |
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| References | 1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695. |
| Molecular Formula | C19H18N2Os |
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| Molecular Weight | 322.426 |