UC-514321
Modify Date: 2025-08-22 17:32:10
UC-514321 structure
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Common Name | UC-514321 | ||
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| CAS Number | 299420-83-0 | Molecular Weight | 441.568 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H35NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UC-514321UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent. |
| Name | UC-514321 |
|---|
| Description | UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent. |
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| Related Catalog | |
| Target |
STAT3 STAT5 |
| In Vitro | UC-514321 increases apoptosis in AML cells not in normal HSPCs[1]. UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently[1]. Cell Viability Assay[1] Cell Line: MONOMAC-6, THP-1, KOCL-48, KASUMI-1, ML-2, and NB4 cells. Concentration: 0-500 nM. Incubation Time: 48 hours. Result: Most significantly repressed MONOMAC-6 cell viability. Showed no inhibitory effect on the viability of TET1-low AML. RT-PCR[1] Cell Line: MONOMAC-6 cells. Concentration: 0-500 nM. Incubation Time: 48 hours. Result: Functioned as TET1-transcription inhibitors in TET1-high AMLs and their anti-leukemic effects are TET1-dependent. |
| In Vivo | UC-514321 (2.5 mg/kg, ip, once per day, for 10 days) exhibits more potant anti-tumor activity than NSC370284 in AML mice models[1]. Animal Model: MLL-AF9-AML mice and AE9a-AML model[1]. Dosage: 2.5 mg/kg. Administration: IP., once per day, for 10 days. Result: Showed an improved therapeutic effect in AML mouse models in vivo. Prolonged the median survival over three fold. |
| References |
| Molecular Formula | C26H35NO5 |
|---|---|
| Molecular Weight | 441.568 |
| InChIKey | XNARHFDDQALZPZ-UHFFFAOYSA-N |
| SMILES | CC(C)(C)c1cc(C(c2cc3c(cc2O)OCO3)N2CCOCC2)cc(C(C)(C)C)c1O |