BTK-IN-22

Modify Date: 2024-04-09 00:26:58

BTK-IN-22 Structure
BTK-IN-22 structure
 Common Name BTK-IN-22
CAS Number 2573048-10-7 Molecular Weight 454.52
Density N/A Boiling Point N/A
Molecular Formula C26H26N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BTK-IN-22


BTK-IN-22 is a BTK inhibitor (IC50: 0.9 nM). BTK-IN-22 also inhibits BLX and BMX with IC50s of 1.4 and 1.2 nM respectively. BTK-IN-22 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1]

 Names

Name BTK-IN-22

 BTK-IN-22 Biological Activity

Description BTK-IN-22 is a BTK inhibitor (IC50: 0.9 nM). BTK-IN-22 also inhibits BLX and BMX with IC50s of 1.4 and 1.2 nM respectively. BTK-IN-22 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1]
Related Catalog
In Vitro BTK-IN-23 (Compound 2) 抑制 Jeko-1 细胞中 BTK 自磷酸化，IC50 值为 109 nM[1]. Western Blot Analysis[1] Cell Line: Jeko-1 cell Concentration: 0.01, 0.1, 1, 10 μM Incubation Time: 2 h Result: Inhibited BTK autophosphorylation.
References

[1]. Sean T. Toenjes, et al. Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med. Chem. Lett. 2023. https://doi.org/10.1021/acsmedchemlett.2c00523

 Chemical & Physical Properties

Molecular Formula C26H26N6O2
Molecular Weight 454.52
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Chemsrc provides BTK-IN-22(CAS#:2573048-10-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BTK-IN-22 are included as well.>> amp version: BTK-IN-22

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