BTK-IN-23

Modify Date: 2024-04-08 18:42:45

BTK-IN-23 structure	Common Name	BTK-IN-23
	CAS Number	2573048-11-8	Molecular Weight	468.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₈N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BTK-IN-23

BTK-IN-23 is a BTK inhibitor (IC50: 12.8 nM). BTK-IN-23 also inhibits BLX and BMX with IC50s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1].

Name	BTK-IN-23

Description	BTK-IN-23 is a BTK inhibitor (IC50: 12.8 nM). BTK-IN-23 also inhibits BLX and BMX with IC50s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
In Vitro	BTK-IN-23 (化合物 3) 抑制 Jeko-1 细胞中的 BTK 自磷酸化，IC50 为 314 nM[1]。 Western Blot Analysis[1] Cell Line: Jeko-1 cell Concentration: 0.01, 0.1, 1, 10 μM Incubation Time: 2 h Result: Inhibited BTK autophosphorylation.
References	[1]. Sean T. Toenjes, et al. Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med. Chem. Lett. 2023. https://doi.org/10.1021/acsmedchemlett.2c00523

Molecular Formula	C₂₇H₂₈N₆O₂
Molecular Weight	468.55