SC 22716

Modify Date: 2024-01-15 10:01:53

SC 22716 Structure
SC 22716 structure
Common Name SC 22716
CAS Number 262451-89-8 Molecular Weight 267.36500
Density 1.065g/cm3 Boiling Point 418.5ºC at 760 mmHg
Molecular Formula C18H21NO Melting Point N/A
MSDS USA Flash Point 122.8ºC

 Use of SC 22716


SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis[1].

 Names

Name 1-[2-(4-phenylphenoxy)ethyl]pyrrolidine
Synonym More Synonyms

 SC 22716 Biological Activity

Description SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis[1].
Related Catalog
References

[1]. Penning TD, et, al. Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. J Med Chem. 2000 Feb 24;43(4):721-35.

 Chemical & Physical Properties

Density 1.065g/cm3
Boiling Point 418.5ºC at 760 mmHg
Molecular Formula C18H21NO
Molecular Weight 267.36500
Flash Point 122.8ºC
Exact Mass 267.16200
PSA 12.47000
LogP 3.76610
Vapour Pressure 3.27E-07mmHg at 25°C
Index of Refraction 1.568

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Synthetic Route

~%

SC 22716 Structure

SC 22716

CAS#:262451-89-8

Literature: Penning, Thomas D.; Chandrakumar, Nizal S.; Chen, Barbara B.; Chen, Helen Y.; Desai, Bipin N.; Djuric, Stevan W.; Docter, Stephen H.; Gasiecki, Alan F.; Haack, Richard A.; Miyashiro, Julie M.; Russell, Mark A.; Yu, Stella S.; Corley, David G.; Durley, Richard C.; Kilpatrick, Brian F.; Parnas, Barry L.; Askonas, Leslie J.; Gierse, James K.; Harding, Elizabeth I.; Highkin, Maureen K.; Kachur, James F.; Kim, Suzanne H.; Krivi, Gwen G.; Villani-Price, Doreen; Pyla, E. Yvonne; Smith, Walter G.; Ghoreishi-Haack, Nayereh S. Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 721 - 735

~%

SC 22716 Structure

SC 22716

CAS#:262451-89-8

Literature: Adir et Compagnie Patent: US6339092 B1, 2002 ; Location in patent: Page column 5 ;

 Synonyms

1-[2-(biphenyloxy)ethyl]pyrrolidine
1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine