Benzisothiazolone

Modify Date: 2024-01-02 10:15:59

Benzisothiazolone structure	Common Name	Benzisothiazolone
	CAS Number	2634-33-5	Molecular Weight	151.19
	Density	1.4±0.1 g/cm3	Boiling Point	204.5±23.0 °C at 760 mmHg
	Molecular Formula	C₇H₅NOS	Melting Point	154-158ºC
	MSDS	Chinese USA	Flash Point	77.5±22.6 °C
	Symbol	GHS05, GHS07, GHS09	Signal Word	Danger

Use of Benzisothiazolone

Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coli ATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model [1].

Name	benzo[d]isothiazol-3-one
Synonym	More Synonyms

Description	Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coli ATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model [1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. CollierPJ, et al. Growth inhibitory and biocidal activity of some isothiazolonebiocides. J Appl Bacteriol. 1990 Oct;69(4):569-77.

Density	1.4±0.1 g/cm3
Boiling Point	204.5±23.0 °C at 760 mmHg
Melting Point	154-158ºC
Molecular Formula	C₇H₅NOS
Molecular Weight	151.19
Flash Point	77.5±22.6 °C
Exact Mass	151.009186
PSA	61.10000
LogP	1.78
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.745
Water Solubility	Soluble in dichloromethane, dimethyl sulfoxide, methanol.

Benzisothiazolone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4620000

CHEMICAL NAME :: 1,2-Benzisothiazol-3(2H)-one

CAS REGISTRY NUMBER :: 2634-33-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H5-N-O-S

MOLECULAR WEIGHT :: 151.19

WISWESSER LINE NOTATION :: T56 BSMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1020 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9375 No. of Facilities: 4586 (estimated) No. of Industries: 57 No. of Occupations: 57 No. of Employees: 92923 (estimated) No. of Female Employees: 15307 (estimated)

Symbol	GHS05, GHS07, GHS09
Signal Word	Danger
Hazard Statements	H302-H315-H317-H318-H400
Precautionary Statements	P273-P280-P301 + P312 + P330-P305 + P351 + P338 + P310-P333 + P313-P391
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R38;R41;R43;R50
Safety Phrases	S24-S26-S37/39-S61
RIDADR	UN 3077
WGK Germany	2
RTECS	DE4620000
Packaging Group	III
HS Code	2934200090

Precursor 9
CAS#:5697-20-1 2-sulfanylbenzamide CAS#:873-32-5 2-Chlorobenzonitrile CAS#:6609-54-7 2-(methylthio)b... CAS#:3950-02-5 Benzoyl chlorid...
CAS#:2527-57-3 2-[(2-carbamoyl... CAS#:5459-63-2 Dimethyl 2,2'-d... CAS#:94266-24-7 methyl 2-(amino... CAS#:54705-16-7 2-methylsulfany...
CAS#:256947-56-5 ethyl 2-aminosu...
DownStream 10
CAS#:14599-38-3 1-oxo-1,2-benzo... CAS#:19767-25-0 3-(2-piperidin-... CAS#:2527-57-3 2-[(2-carbamoyl... CAS#:87691-87-0 3-(1-Piperaziny...
CAS#:7716-66-7 3-Chlor-1,2-ben... CAS#:81-07-2 Saccharin CAS#:2527-03-9 2-phenyl-1,2-be... CAS#:35159-81-0 2-prop-2-enyl-1...
CAS#:2527-66-4 2-Methyl-1,2-be... CAS#:2514-30-9 PBIT

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.

Bioorg. Med. Chem. Lett. 21(24) , 7321-4, (2011)

The regulation of 2-arachidonoylglycerol (2-AG) levels is a major issue as 2-AG has been proven to participate in numerous physiopathological phenomena such as neuroprotection or analgesia. Octhilinon...

Solid-phase synthesis of benzisothiazolones as serine protease inhibitors.

Bioorg. Med. Chem. Lett. 9(5) , 663-6, (1999)

An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been...

A colorimetric assay for high-throughput screening of inhibitors of herpes simplex virus type 1 alkaline nuclease.

Anal. Biochem. 293(2) , 239-45, (2001)

Herpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alkaline nuclease (AN) because of its elevated pH optimum. Studies with recombinant viruses which cont...

Benzisothiazolone

2,3-dihydro-3-oxo-1,2-benzisothiazole

benzo[d]isothiazol-3-one

Proxan

proxel

Proxel AB

proxil

1,2-Benzothiazol-3-ol

EINECS 220-120-9

Benzisothiazolone (BIT)

1,2-benzoisothiazolin-3-one

BIOCIDE--BIT

Proxel XL

MFCD00127753

T56 BSMVJ

Benzocil

1,2-benzisothiazol-3-one

1,2-Benzisothiazol-3(2H)-one

T56 BSNJ DQ

BIT

proxelpl

1,2-Benzisothiazolin-3-One

1,2-Benzothiazol-3(2H)-one

PROXELHL

1,2-Benzisothiazol-3-ol

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Benzisothiazolone
Price: ￥68.0/25g ￥258.0/100g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,2-Benzisothiazolin-3-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 1,2-Benzisothiazol-3(2H)-one
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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