Benzisothiazolone

Modify Date: 2024-01-02 10:15:59

Benzisothiazolone Structure
Benzisothiazolone structure
 Common Name Benzisothiazolone
CAS Number 2634-33-5 Molecular Weight 151.19
Density 1.4±0.1 g/cm3 Boiling Point 204.5±23.0 °C at 760 mmHg
Molecular Formula C7H5NOS Melting Point 154-158ºC
MSDS Chinese USA Flash Point 77.5±22.6 °C
Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09		 Signal Word Danger

 Use of Benzisothiazolone


Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coli ATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model [1].

 Names

Name benzo[d]isothiazol-3-one
Synonym More Synonyms

 Benzisothiazolone Biological Activity

Description Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coli ATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model [1].
Related Catalog
References

[1]. CollierPJ, et al. Growth inhibitory and biocidal activity of some isothiazolonebiocides. J Appl Bacteriol. 1990 Oct;69(4):569-77.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 204.5±23.0 °C at 760 mmHg
Melting Point 154-158ºC
Molecular Formula C7H5NOS
Molecular Weight 151.19
Flash Point 77.5±22.6 °C
Exact Mass 151.009186
PSA 61.10000
LogP 1.78
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.745
Water Solubility Soluble in dichloromethane, dimethyl sulfoxide, methanol.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE4620000
CHEMICAL NAME :
1,2-Benzisothiazol-3(2H)-one
CAS REGISTRY NUMBER :
2634-33-5
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C7-H5-N-O-S
MOLECULAR WEIGHT :
151.19
WISWESSER LINE NOTATION :
T56 BSMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1020 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9375 No. of Facilities: 4586 (estimated) No. of Industries: 57 No. of Occupations: 57 No. of Employees: 92923 (estimated) No. of Female Employees: 15307 (estimated)

 Safety Information

Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger
Hazard Statements H302-H315-H317-H318-H400
Precautionary Statements P273-P280-P301 + P312 + P330-P305 + P351 + P338 + P310-P333 + P313-P391
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R38;R41;R43;R50
Safety Phrases S24-S26-S37/39-S61
RIDADR UN 3077
WGK Germany 2
RTECS DE4620000
Packaging Group III
HS Code 2934200090

 Synthetic Route

 Preparation


 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles26

More Articles
Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.

Bioorg. Med. Chem. Lett. 21(24) , 7321-4, (2011)

The regulation of 2-arachidonoylglycerol (2-AG) levels is a major issue as 2-AG has been proven to participate in numerous physiopathological phenomena such as neuroprotection or analgesia. Octhilinon...

Solid-phase synthesis of benzisothiazolones as serine protease inhibitors.

Bioorg. Med. Chem. Lett. 9(5) , 663-6, (1999)

An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been...

A colorimetric assay for high-throughput screening of inhibitors of herpes simplex virus type 1 alkaline nuclease.

Anal. Biochem. 293(2) , 239-45, (2001)

Herpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alkaline nuclease (AN) because of its elevated pH optimum. Studies with recombinant viruses which cont...

 Synonyms

Benzisothiazolone
2,3-dihydro-3-oxo-1,2-benzisothiazole
benzo[d]isothiazol-3-one
Proxan
proxel
Proxel AB
proxil
1,2-Benzothiazol-3-ol
EINECS 220-120-9
Benzisothiazolone (BIT)
1,2-benzoisothiazolin-3-one
BIOCIDE--BIT
Proxel XL
MFCD00127753
T56 BSMVJ
Benzocil
1,2-benzisothiazol-3-one
1,2-Benzisothiazol-3(2H)-one
T56 BSNJ DQ
BIT
proxelpl
1,2-Benzisothiazolin-3-One
1,2-Benzothiazol-3(2H)-one
PROXELHL
1,2-Benzisothiazol-3-ol
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