Apiin

Modify Date: 2025-08-23 07:55:06

Apiin Structure
Apiin structure
Common Name Apiin
CAS Number 26544-34-3 Molecular Weight 564.492
Density 1.7±0.1 g/cm3 Boiling Point 942.2±65.0 °C at 760 mmHg
Molecular Formula C26H28O14 Melting Point 230ºC (dec.)
MSDS Chinese USA Flash Point 316.7±27.8 °C

 Use of Apiin


Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells[1].

 Names

Name Apiin
Synonym More Synonyms

 Apiin Biological Activity

Description Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells[1].
Related Catalog
References

[1]. Mencherini T, et al. An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J Pharm Pharmacol. 2007 Jun;59(6):891-7.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 942.2±65.0 °C at 760 mmHg
Melting Point 230ºC (dec.)
Molecular Formula C26H28O14
Molecular Weight 564.492
Flash Point 316.7±27.8 °C
Exact Mass 564.147888
PSA 228.97000
LogP 0.74
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.744
InChIKey NTDLXWMIWOECHG-YRCFQSNFSA-N
SMILES O=c1cc(-c2ccc(O)cc2)oc2cc(OC3OC(CO)C(O)C(O)C3OC3OCC(O)(CO)C3O)cc(O)c12
Storage condition 2-8C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 1
HS Code 29389090

 Precursor & DownStream

Precursor  0

DownStream  3

 Articles7

More Articles
Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants.

Anal. Bioanal. Chem 407(1) , 265-77, (2015)

In this paper, we describe the findings of a study aimed at assessing the detection sensitivity of comprehensive two-dimensional high-performance liquid chromatography (LCxLC) separation of a degraded...

Bioavailability of apigenin from apiin-rich parsley in humans.

Ann. Nutr. Metab. 50(3) , 167-72, (2006)

Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested.Eleven healthy subjects (5 women, 6 men) in the age range of 23-41 years and with an average body ...

[Studies on the chemical constituents of the aerial parts of Seseli mairei].

Zhong Yao Cai 30(1) , 42-4, (2007)

To study the chemical constituents of the aerial parts of Seseli mairei Wolf.The chemical constituents have been separated with manifold chromatography methods, and their structures were determined hy...

 ApiinBioassay

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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: HepG2 viability counterscreen (readout 2: ATP content) against the NCATS DSHEA and TC...
Source: NCGC
Target: N/A
External Id: DSHEA-v1-HepG2-viability-CTG-ATP
Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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 Synonyms

APIIN
Apioside
APIGENIN-7-APIOGLUCOSIDE
5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 4-O-[(3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]-β-D-glucopyranoside
apigenin-7-O-apiosyl(1->2)glucoside
apigenin 7-O-apiosylglucoside
4',5,7-Trihydroxyflavone-7-apiosylglucoside
5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 4-O-[(3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
7-(2-APIOSYLGLUCOSYL)APIGENIN
Apigenin-7-(2-O-apiosylglucoside)
7-[(2-O-D-Apio-b-D-furanosyl-b-D-glucopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Apigenin-7-apiosylglucoside
EINECS 247-780-0
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