IRAK4-IN-13

Modify Date: 2025-09-24 18:23:24

IRAK4-IN-13 structure	Common Name	IRAK4-IN-13
	CAS Number	2667681-57-2	Molecular Weight	457.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₇N₉O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IRAK4-IN-13

IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg[1].

Name	IRAK4-IN-13

Description	IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:0.6 nM (IC50)
In Vitro	IRAK4-IN-13 (compound 21) shows cell pIRAK4 potencies with an IC50 of 0.024 µM[1]. IRAK4-IN-13 (compound 21) shows selectivity with IC50s of 0.0006, 0.002, 0.044, 1.2, 0.018, 0.019, 0.082, 0.036 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively[1].
References	[1]. Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815.

Molecular Formula	C₂₄H₂₇N₉O
Molecular Weight	457.53

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