Amoxicillin

Modify Date: 2024-01-01 19:45:49

Amoxicillin Structure
Amoxicillin structure
 Common Name Amoxicillin
CAS Number 26787-78-0 Molecular Weight 365.404
Density 1.6±0.1 g/cm3 Boiling Point 701.8±70.0 °C at 760 mmHg
Molecular Formula C16H19N3O5S Melting Point N/A
MSDS Chinese USA Flash Point 378.2±35.7 °C
Symbol GHS08
GHS08		 Signal Word Danger

 Use of Amoxicillin


Amoxicillin is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.Target: AntibacterialAmoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a narrow spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid, a β-lactamase inhibitor. This increases effectiveness by reducing its susceptibility to β-lactamase resistance. From Wikipedia.

 Names

Name amoxicillin
Synonym More Synonyms

 Amoxicillin Biological Activity

Description Amoxicillin is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.Target: AntibacterialAmoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a narrow spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid, a β-lactamase inhibitor. This increases effectiveness by reducing its susceptibility to β-lactamase resistance. From Wikipedia.
Related Catalog
References

[1]. http://en.wikipedia.org/wiki/Amoxicillin

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 701.8±70.0 °C at 760 mmHg
Molecular Formula C16H19N3O5S
Molecular Weight 365.404
Flash Point 378.2±35.7 °C
Exact Mass 365.104553
PSA 158.26000
LogP 0.92
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.745
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH8300000
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl) amino)-3,3-dimethyl-7-oxo-
CAS REGISTRY NUMBER :
26787-78-0
LAST UPDATED :
199603
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C16-H19-N3-O5-S
MOLECULAR WEIGHT :
365.44
WISWESSER LINE NOTATION :
T45 ANV ESTJ CMVYZR DQ& F1 F1 GVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
40 mg/kg/4D
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,707,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
682 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - hematuria
REFERENCE :
CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 32,735,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2870 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>25 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,38,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3590 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,59,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 26,196,1980 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
3 gm/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
AGSREJ Arab Gulf Journal of Scientific Research. (Arab Bureau of Education for the Gulf States, POB 3908, Riyadh, 11481, Saudi Arabia) V.7 No.2- 1989- Volume(issue)/page/year: 12,133,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3562 No. of Facilities: 921 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 24519 (estimated) No. of Female Employees: 10563 (estimated)

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H317-H334
Precautionary Statements P261-P280-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R42/43
Safety Phrases S22-S36/37
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS XH8300000
HS Code 2941109200

 Synthetic Route

 Customs

HS Code 2941109200

 Articles364

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 Synonyms

Intermox
Lamoxy
A-Gram
Novenzymin
Amoxin
Amoxtrex
AMOX
Amoxa
Imaxilin
Uro-clamoxyl
Imox
Rancil
Moxylin
Ampidroxyl
MOx
Excillin
Tolodina
[2S-[2a,5a,6b(S*)]]-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Protexillin
Samosillin
Amoxy
Bridopen
Ranmoxy
Grunamox
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Jerramcil
Kamoxin
Amoxaren
Zamocillin
Damoxicil
Zamocilline
Larocilin
Cilamox
Amoxy-diolan
Rhamoxilina
Zerrsox
Amoxicillin
Limox
Agerpen
Pasetocin
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1E,2R)-2-amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Gomcillin
Amoxal
Gemox
(2S,5R,6R)-6-{(E)-[(2R)-2-Amino-1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Sigmopen
Amoxine
Comoxyl
Moxaline
Zimox
amoxil
Bioxidona
blp1410
Amoxi-Diolan
Eupen
Alphamox
Azillin
6-[D(-)-a-Amino-p-hydroxyphenylacetamido]penicillanic Acid
Zamox
Amoxina
Amagesen Solutab
Amoxi-basan
Amoxidal
Amoxillat
Suramox PM
amolin
Amoxisol
Amoxicillin-ratiopharm
Simplamox
Draximox
Amoxihexal
[2S,5R,6R]-6-[[[2R]-Amino[4-hydroxyphenyl]acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Optium
Moxlin
Virgoxillin
Trimox
Mopen
EINECS 248-003-8
Clamox
a-Amino-p-hydroxybenzylpenicillin
Amoxibiotic
Meixil
Hipen
Galenamox
Moxilen
Amoxipenil
Farconcil
Rocillin
Amosine
Gimalxina
Ciblor
Zamoxil
Anemol
α-Amino-p-hydroxybenzylpenicillin
Bioxyllin
PENSYN
Triafamox
Moxarin
amoxi
Morgenxil
Amoran
Moxyvit
Grinsul
p-Hydroxyampicillin
Amophar
Amopen
Amodex
(2S,5R,6R)-6-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Moxypen
Reloxyl
MFCD00072029
Apo-Amoxi
Efpinex
Ikamoxil
Amoxi-wolff
Sil-A-mox
Audumic
Alfamox
Bimox
Fullcilina
Ospamox
Triamoxil
Teramoxyl
Matasedrin
Penbiosyn
Ronemox
Amoxivan
Fisamox
Moxcil
Amoxillin
Winmox
Amcill
Amoxapen
Amoxipen
Pamoxicillin
Amo-flamsian
Abdimox
Biomox
Novabritine
Himinomax
Pacetocin
Posmox
6-(p-Hydroxy-α-aminophenylacetamido)penicillanic acid
Novamoxin
Yisulon
Ranoxyl
Sintopen
Isimoxin
Acimox
Amoxcillin
Samthongcillin
Bintamox
Velamox
Gramidil
clavulanate
Twicyl
Adbiotin
6-(p-Hydroxy-a-aminophenylacetamido)penicillanic Acid
Majorpen
Saltermox
Sia-mox
Izoltil
Amoflux
Utimox
Flemoxine
Imoxil
Paradroxil
Foxolin
Hidramox
Pamocil
Specillin
Kentrocyllin
Senox
Actimoxi
Trilaxin
Superpeni
amoxycillin
(-)-6-[2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
Bactamox
Medimox
Sawamezin
Dura AX
Maxcil
Apitart
Coamoxin
Hosboral
sumox
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Related Compounds: More...
AMOXICILLIN
81030-75-3
L-Amoxicillin
26889-93-0
Amoxicillin dimer
73590-06-4
AMoxicillin TriMer
174391-69-6
Amoxicillin sodium
34642-77-8
AmoxicillinTrihydrate
61336-70-7
Amoxicillin Impurity 5
1356020-01-3
Amoxicillin Impurity 4
68728-47-2
Amoxicillin Impurity 3
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1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
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N-[2-(5-chlorothiophen-2-yl)-2-methoxyethyl]-2-oxoimidazolidine-1-carboxamide
2034598-34-8
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
5-fluoro-1-phenyl-1H-pyrazol-4-amine hydrochloride
1803593-08-9
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