URAT1 inhibitor 4
Modify Date: 2024-07-09 11:22:59
URAT1 inhibitor 4 structure
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Common Name | URAT1 inhibitor 4 | ||
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| CAS Number | 2700292-02-8 | Molecular Weight | 626.56 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H20BrN3O4S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of URAT1 inhibitor 4URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258)[1]. |
| Name | URAT1 inhibitor 4 |
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| Description | URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258)[1]. |
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| Related Catalog | |
| Target |
IC50: 7.56 ± 0.52 μM (URAT1), 55.96 ± 10.38 μM (GLUT9)[1] |
| In Vitro | URAT1 inhibitor 4 (化合物 10) 抑制 URAT1 和 GLUT9，IC50 分别为 7.56 ± 0.52 μM 和 55.96 ± 10.38 μM[1]。 |
| In Vivo | URAT1 inhibitor 4 (2 mg/kg；单次口服) 降低急性高尿酸血症模型小鼠血清尿酸水平[1]。 URAT1 inhibitor 4 (1000 mg/kg; 单次灌胃) 在小鼠急性毒性评估中比 Lesinurad 的存活率更高。 Animal Model: Kunming mice (acute hyperuricemia model)[1] Dosage: 2 mg/kg Administration: p.o.; single dosage Result: Decreased serum uric acid with an decrease ratio of 73.29%. Animal Model: Kunming mice[1] Dosage: 1000 mg/kg Administration: i.g.; single dosage Result: Survival rate was 100% after 7 days, while Lesinurad were 40% (male) and 20% (female). |
| References |
| Molecular Formula | C27H20BrN3O4S3 |
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| Molecular Weight | 626.56 |