LE 300

Modify Date: 2024-01-03 09:32:08

LE 300 structure	Common Name	LE 300
	CAS Number	274694-98-3	Molecular Weight	290.40200
	Density	1.114g/cm3	Boiling Point	464ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₂N₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	234.4ºC

Use of LE 300

LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2].

Name	le 300
Synonym	More Synonyms

Description	LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	Human D1 Receptor:1.9 nM (Ki) Human D5 Receptor:7.5 nM (Ki) Rat 5-HT2A:8.32 (pA2)
References	[1]. Kassack MU, et al. Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a novel type of a nanomolar dopamine receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2002 Dec;366(6):543-50. [2]. Rostom SA. Novel fused pyrrole heterocyclic ring systems as structure analogs of LE 300: Synthesis and pharmacological evaluation as serotonin 5-HT(2A), dopamine and histamine H(1) receptor ligands. Arch Pharm (Weinheim). 2010 Feb;343(2):73-80.

Density	1.114g/cm3
Boiling Point	464ºC at 760 mmHg
Molecular Formula	C₂₀H₂₂N₂
Molecular Weight	290.40200
Flash Point	234.4ºC
Exact Mass	290.17800
PSA	19.03000
LogP	3.72700
Vapour Pressure	8.69E-09mmHg at 25°C
Index of Refraction	1.63

Tocris-1674

Lopac-L-8401

LE 300

Use of LE 300

Names

LE 300 Biological Activity

Chemical & Physical Properties

Synonyms