HYPOTAURINE
HYPOTAURINE structure
|
Common Name | HYPOTAURINE | ||
|---|---|---|---|---|
| CAS Number | 300-84-5 | Molecular Weight | 109.147 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 354.9±44.0 °C at 760 mmHg | |
| Molecular Formula | C2H7NO2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 168.5±28.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of HYPOTAURINEHypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. |
| Name | hypotaurine |
|---|---|
| Synonym | More Synonyms |
| Description | Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan[1]. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion[2]. |
| In Vivo | Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord[3]. |
| Animal Admin | Rats: A radiant heat source is focused on the middle part of the rat’s tail. The time interval from the onset of the stimulus until the tail flick response is measured using a tail flick unit. The intensity of the radiant heat is adjusted to give a tail flick latency of 4–5 s before the administration of hypotaurine or saline. In the absence of a response, the stimulus is terminated after 15 s (cutoff) to prevent tissue damage. The effects of hypotaurine (100, 200, 400, and 600 μg) on thermal nociception are assessed repeatedly for 120 min post-injection[3]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 354.9±44.0 °C at 760 mmHg |
| Molecular Formula | C2H7NO2S |
| Molecular Weight | 109.147 |
| Flash Point | 168.5±28.4 °C |
| Exact Mass | 109.019745 |
| PSA | 82.53000 |
| LogP | -2.03 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.616 |
| Storage condition | Desiccate at RT |
| Water Solubility | H2O: 100 mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2930909090 |
|
~%
HYPOTAURINE CAS#:300-84-5 |
| Literature: Journal of the American Chemical Society, , vol. 79, p. 5217,5219 |
|
~%
HYPOTAURINE CAS#:300-84-5 |
| Literature: Amino Acids, , vol. 44, # 2 p. 391 - 404 |
|
~%
HYPOTAURINE CAS#:300-84-5 |
| Literature: Bulletin de la Societe Chimique de France, , p. 820 |
|
~%
HYPOTAURINE CAS#:300-84-5 |
| Literature: Biochemical Preparations, , vol. 10, p. 72 |
|
~%
HYPOTAURINE CAS#:300-84-5 |
| Literature: Radiation Research, , vol. 3, p. 393 |
| Precursor 6 | |
|---|---|
| DownStream 4 | |
CAS#:113830-99-2
CAS#:113831-00-8
CAS#:2937-54-4| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|
Paternal breed effects on expression of IGF-II, BAK1 and BCL2-L1 in bovine preimplantation embryos.
Zygote 23 , 712-21, (2015) The effects of the paternal breed on early embryo and later pre- and postnatal development are well documented. Several recent studies have suggested that such paternal effects may be mediated by the ... |
|
|
Sulfur amino acid metabolism in Zucker diabetic fatty rats.
Biochem. Pharmacol. 96 , 256-66, (2015) The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocyste... |
|
|
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
Nature 457(7231) , 910-4, (2009) Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i... |
| Ethanesulfinic acid, 2-amino- |
| 2-Aminoethanesulfinic acid |
| 2-Amino-aethansulfinsaeure |
| MFCD00038197 |
| aminoethylsulfinic acid |
| 2-amino-Ethanesulfinic acid |
| 2-aminoethanesulfinate |
| Cystaminesulfinic acid |
| 2-Aminoethylsulfinate |
| 2-Aminoethylsulfinic acid |
| Ethanesulfinic acid,2-amino |
| Hypotaurine |
| Cystaminesulfinate |