2-Aminoethanethiol

Modify Date: 2025-08-21 14:17:18

2-Aminoethanethiol structure	Common Name	2-Aminoethanethiol
	CAS Number	60-23-1	Molecular Weight	77.149
	Density	1.0±0.1 g/cm3	Boiling Point	133.6±23.0 °C at 760 mmHg
	Molecular Formula	C₂H₇NS	Melting Point	95°C
	MSDS	USA	Flash Point	34.6±22.6 °C
	Symbol	GHS07	Signal Word	Warning

Use of 2-Aminoethanethiol

Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2].

Name	cysteamine
Synonym	More Synonyms

Description	Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6. [2]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

References

[1]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.

[2]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.

Density	1.0±0.1 g/cm3
Boiling Point	133.6±23.0 °C at 760 mmHg
Melting Point	95°C
Molecular Formula	C₂H₇NS
Molecular Weight	77.149
Flash Point	34.6±22.6 °C
Exact Mass	77.029922
PSA	64.82000
LogP	0.03
Vapour Pressure	8.4±0.2 mmHg at 25°C
Index of Refraction	1.486
Stability	Stable, but may be air-sensitive. Incompatible with strong oxidizing agents.

2-Aminoethanethiol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ0175000

CHEMICAL NAME :: Ethanethiol, 2-amino-

CAS REGISTRY NUMBER :: 60-23-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C2-H7-N-S

MOLECULAR WEIGHT :: 77.16

WISWESSER LINE NOTATION :: Z2SH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 232 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 42 gm/kg

SEX/DURATION :: female 70 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,351,1979

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	3259
WGK Germany	3
RTECS	KJ0175000

Precursor 9
CAS#:156-57-0 Cysteamine Hydr... CAS#:151-56-4 Aziridine CAS#:1095-85-8 Ethanamine,2-[(... CAS#:7783-06-4 hydrogen sulfide
CAS#:177-07-1 1-thia-4-azaspi... CAS#:2937-53-3 Thiosulfuric ac... CAS#:52-90-4 L-cysteine CAS#:51-85-4 Cystamine
CAS#:70-18-8 Glutathione
DownStream 9
CAS#:108-02-1 2-(DIMETHYLAMIN... CAS#:4569-82-8 2-phenylthiazolidine CAS#:31404-08-7 Thiazolidine,2-... CAS#:1420-88-8 N,S-Diacetylcys...
CAS#:1779-81-3 Aminothiazoline CAS#:504-78-9 Thiazolidine CAS#:504-79-0 4,5-dihydro-1,3... CAS#:21226-52-8 2-pentyl-4,5-di...
CAS#:70-18-8 Glutathione

Mediated Electron Transfer at Vertically Aligned Single-Walled Carbon Nanotube Electrodes During Detection of DNA Hybridization.

Nanoscale Res. Lett. 10 , 978, (2015)

Vertically aligned single-walled carbon nanotube (VASWCNT) assemblies are generated on cysteamine and 2-mercaptoethanol (2-ME)-functionalized gold surfaces through amide bond formation between carboxy...

A nanoplasmonic biosensor for label-free multiplex detection of cancer biomarkers.

Biosens. Bioelectron. 74 , 341-6, (2015)

The development of highly sensitive, selective and multiplex sensors has become an important challenge for disease diagnosis. In this study, we describe a multiplex biosensor for the detection of canc...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

b-MEA

Ethanethiol, 2-amino-

2-Aminoethanethiol

Thioethanolamine

β-aminoethylthiol

β-mercaptoethylamine

Mercamine

MEA

mercaptoethylamine

mercaptamine

b-Aminoethylthiol

Merkamin

b-Aminoethanethiol

Mercaptamin

2-mercaptoethylamine

b-Mercaptoethylamine

MFCD00008196

cysteamine

Decarboxycysteine

β-Aminoethanethiol

EINECS 200-463-0

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2-Aminoethanethiol

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