1,4-Bis[(2H)sulfanyl]-2,3-(2H6)butane(2H2)diol

Modify Date: 2024-01-02 08:33:34

1,4-Bis[(2H)sulfanyl]-2,3-(2H6)butane(2H2)diol Structure
1,4-Bis[(2H)sulfanyl]-2,3-(2H6)butane(2H2)diol structure
Common Name 1,4-Bis[(2H)sulfanyl]-2,3-(2H6)butane(2H2)diol
CAS Number 302912-05-6 Molecular Weight 164.313
Density 1.3±0.1 g/cm3 Boiling Point 364.5±42.0 °C at 760 mmHg
Molecular Formula C4D10O2S2 Melting Point 42-44ºC(lit.)
MSDS Chinese USA Flash Point 174.2±27.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 1,4-Bis[(2H)sulfanyl]-2,3-(2H6)butane(2H2)diol


DL-dithiothreitol-d10 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].

 Names

Name 1,1,2,3,4,4-hexadeuterio-2,3-dideuteriooxy-1,4-bis(deuteriosulfanyl)butane
Synonym More Synonyms

  Biological Activity

Description DL-dithiothreitol-d10 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Dithiothreitol, From Wikipedia

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 364.5±42.0 °C at 760 mmHg
Melting Point 42-44ºC(lit.)
Molecular Formula C4D10O2S2
Molecular Weight 164.313
Flash Point 174.2±27.9 °C
Exact Mass 164.074982
PSA 118.06000
LogP 0.07
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.579

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xn: Harmful;
Risk Phrases 22-36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport

 Synonyms

DL-Dithiothreitol-d10
Cleland's reagent-d10
1,4-Bis[(H)sulfanyl]-2,3-(H)butane(H)diol
2,3-Butane-1,1,2,3,4,4-d-diol-d, 1,4-di(mercapto-d)-
Cleland inverted exclamation mark s reagent-d10
MFCD00190434