Theaflavin 3,3'-di-O-gallate

Modify Date: 2024-01-03 20:13:37

Theaflavin 3,3'-di-O-gallate structure	Common Name	Theaflavin 3,3'-di-O-gallate
	CAS Number	30462-35-2	Molecular Weight	868.702
	Density	2.0±0.1 g/cm3	Boiling Point	1324.7±65.0 °C at 760 mmHg
	Molecular Formula	C₄₃H₃₂O₂₀	Melting Point	226-230℃
	MSDS	USA	Flash Point	402.9±27.8 °C

Use of Theaflavin 3,3'-di-O-gallate

Theaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM[1].

Name	[(2R,3R)-2-[1-[(2R,3R)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-3,4-dihydro-2H-chromen-2-yl]-3,4,5-trihydroxy-6-oxobenzo[7]annulen-8-yl]-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Synonym	More Synonyms

Description	Theaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MEK Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	Akt NF-κB MEK1 MEK2 ERK1 ERK2
References	[1]. Ding Y, et al. Pre-treated theaflavin-3,3'-digallate has a higher inhibitory effect on the HCT116 cell line. Food Nutr Res. 2017 Nov 15;61(1):1400340.

Density	2.0±0.1 g/cm3
Boiling Point	1324.7±65.0 °C at 760 mmHg
Melting Point	226-230℃
Molecular Formula	C₄₃H₃₂O₂₀
Molecular Weight	868.702
Flash Point	402.9±27.8 °C
Exact Mass	868.148682
PSA	351.12000
LogP	3.88
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.908

Theaflavin 3,3'-di-O-gallate MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
HS Code	29329990

Precursor 2
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DownStream 0

Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy.

Prostate 75(5) , 550-9, (2015)

Preclinical and epidemiologic studies suggest chemopreventive effects of green tea (GT) and black tea (BT) in prostate cancer. In the current study we determined the effect of GT and BT consumption on...

8-Gingerol

(3,4,5-Trihydroxy-6-oxo-6H-benzo[7]annulene-1,8-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)

theaflavin 3,3'-O-digallate

Theaflavin-3,3'-digallate

theaflavin-3,3'-di-O-gallate

theaflavin 3,3'-gallate

Benzoic acid, 3,4,5-trihydroxy-, (3,4,5-trihydroxy-6-oxo-6H-benzocycloheptene-1,8-diyl)bis[(2R,3R)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl] ester

Theaflavin digallate

TF-3

Theaflavin 3,3'-digallate