Triethylene glycol monododecyl ether

Modify Date: 2025-08-27 20:17:56

Triethylene glycol monododecyl ether Structure
Triethylene glycol monododecyl ether structure
Common Name Triethylene glycol monododecyl ether
CAS Number 3055-94-5 Molecular Weight 318.492
Density 0.9±0.1 g/cm3 Boiling Point 412.0±25.0 °C at 760 mmHg
Molecular Formula C18H38O4 Melting Point N/A
MSDS Chinese USA Flash Point 202.9±23.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Triethylene glycol monododecyl ether


Triethylene glycol monododecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-(2-dodecoxyethoxy)ethoxy]ethanol
Synonym More Synonyms

 Triethylene glycol monododecyl ether Biological Activity

Description Triethylene glycol monododecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 412.0±25.0 °C at 760 mmHg
Molecular Formula C18H38O4
Molecular Weight 318.492
Flash Point 202.9±23.2 °C
Exact Mass 318.277008
PSA 47.92000
LogP 4.33
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.451
Storage condition 2-8°C
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KK7870000
CHEMICAL NAME :
Ethanol, 2-(2-(2-(dodecyloxy)ethoxy)ethoxy)-
CAS REGISTRY NUMBER :
3055-94-5
BEILSTEIN REFERENCE NO. :
1779029
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H38-O4
MOLECULAR WEIGHT :
318.56
WISWESSER LINE NOTATION :
Q2O2O2O12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - guinea pig Kidney
DOSE/DURATION :
10 umol/L
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,431,1976

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
RTECS KK7870000
HS Code 2909499000

 Synthetic Route

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Triethylene glycol monododecyl ether Structure

Triethylene gly...

CAS#:3055-94-5

Literature: Journal of Organic Chemistry, , vol. 25, p. 439 - 444

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Triethylene glycol monododecyl ether Structure

Triethylene gly...

CAS#:3055-94-5

Literature: Bulletin des Societes Chimiques Belges, , vol. 65, p. 453,470

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Triethylene glycol monododecyl ether Structure

Triethylene gly...

CAS#:3055-94-5

Literature: Bulletin des Societes Chimiques Belges, , vol. 65, p. 453,470

~%

Triethylene glycol monododecyl ether Structure

Triethylene gly...

CAS#:3055-94-5

Literature: Bulletin des Societes Chimiques Belges, , vol. 65, p. 453,470

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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 Synonyms

Lauryltriglycol ether
Triethylene glycol monododecyl ether
triiethylene glycol mondodecyl ether
PEG-3 Lauryl ether
Ethanol, 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]-
C12E3 Dodecyl triethylene glycol ether Dodecyltriglycol Polyoxyethylene (3) lauryl ether
Dodecyltriglycol
2-{2-[2-(Dodecyloxy)ethoxy]ethoxy}ethanol
TRIETHYLENE GLYCOL MONO-N-DODECYL ETHER
triethyleneglycol monododecyl ether
Dodecyl triethylene glycol ether
Lauryl triethoxylate
MFCD00042659
Detergent Screening
EINECS 221-280-2
Triethylene glycol dodecyl ether
Triethyleneglycol monododecyl ether 1 mM
Lauryl alcohol triglycol ether
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