EO 1428

Modify Date: 2025-08-26 09:54:56

EO 1428 Structure
EO 1428 structure
 Common Name EO 1428
CAS Number 321351-00-2 Molecular Weight 415.71100
Density 1.483g/cm3 Boiling Point 515.935ºC at 760 mmHg
Molecular Formula C20H16BrClN2O Melting Point N/A
MSDS N/A Flash Point 265.828ºC

 Use of EO 1428


EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1].

 Names

Name [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone
Synonym More Synonyms

 EO 1428 Biological Activity

Description EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1].
Related Catalog
References

[1]. Alasdair J Scott, et al. Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. J Biol Chem. 2011 Oct 14;286(41):35466-35476.

 Chemical & Physical Properties

Density 1.483g/cm3
Boiling Point 515.935ºC at 760 mmHg
Molecular Formula C20H16BrClN2O
Molecular Weight 415.71100
Flash Point 265.828ºC
Exact Mass 414.01300
PSA 55.12000
LogP 6.62190
Index of Refraction 1.689

 Safety Information

HS Code 2922399090

 Synthetic Route

{4-[(4-bromo-2-nitrophenyl)amino]-2-chlorophenyl}(2-methylphenyl)methanone structure

{4-[(4-bromo-2-...

CAS#:321378-18-1

~99%

EO 1428 Structure

EO 1428

CAS#:321351-00-2

Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
2-Chloro-4-nitrobenzoic acid structure

2-Chloro-4-nitr...

CAS#:99-60-5

~%

EO 1428 Structure

EO 1428

CAS#:321351-00-2

Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
(2-Chloro-4-nitrophenyl)(2-methylphenyl)methanone structure

(2-Chloro-4-nit...

CAS#:344459-21-8

~%

EO 1428 Structure

EO 1428

CAS#:321351-00-2

Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
2-Chloro-4-nitrobenzoyl chloride structure

2-Chloro-4-nitr...

CAS#:7073-36-1

~%

EO 1428 Structure

EO 1428

CAS#:321351-00-2

Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
(4-Amino-2-chlorophenyl)(2-methylphenyl)methanone structure

(4-Amino-2-chlo...

CAS#:210967-34-3

~%

EO 1428 Structure

EO 1428

CAS#:321351-00-2

Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662

 Customs

HS Code 2922399090
Summary 2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

eo 1428
hms3266h20
unii-mv2rhj680o
hms3229j13
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Chemsrc provides EO 1428(CAS#:321351-00-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of EO 1428 are included as well.>> amp version: EO 1428

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