SCS
Modify Date: 2024-01-04 00:42:54
SCS structure
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Common Name | SCS | ||
|---|---|---|---|---|
| CAS Number | 3232-36-8 | Molecular Weight | 256.25700 | |
| Density | 1.406g/cm3 | Boiling Point | 427.3ºC at 760mmHg | |
| Molecular Formula | C14H12N2O3 | Melting Point | 280-284°C | |
| MSDS | Chinese USA | Flash Point | 212.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SCSSCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions[1]. |
| Name | SCS,Salicylidenesalicylhydrazide |
|---|---|
| Synonym | More Synonyms |
| Description | SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions[1]. |
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| Related Catalog | |
| Target |
IC50: 32 nM (α2β1γ1θ; by VIPR measurement) IC50: 4.5 nM (α2β1γ1θ), 5.3 nM (α2β1γ1), 7.9 nM (α1β1γ2s) (Measured by using whole-cell patch clamp)[1] |
| In Vitro | SCS (0.1 nM-3 μM) 对表达 α2β1γ1θ、α2β1γ1 和 α1β1γ2s 受体的 Ltk- 细胞的 GABA EC20 电流有浓度依赖性抑制作用，而对 α2β3γ2s 和 α1β2γ2s 受体无影响[1]。 SCS 的抑制不依赖于电压或使用 (not voltage or use dependent)[1]。 SCS 抑制 GABAA 受体所必需的结构决定因素位于 β1 亚基的精氨酸 238 和甘氨酸 335 区域。β1 亚基的 T255 和 I308 对于 SCS 的抑制是必需的[1]。 |
| In Vivo | SCS (Salicylidene salicylhydrazide; 500-1000 mg/kg, i.p. or 800-1000 mg/kg, oral) 使小鼠产生腹部收缩[2]。 SCS (10-75 mg/kg; i.p.; once) 在小鼠中显示出抗强直性和阶段性疼痛和辣椒素痛觉的抗痛觉活性[2]。 SCS (10-75 mg/kg; i.p.; once) 显示小鼠抗炎活性[2]。SCS (50 and 75 mg/kg; i.p.; once) 显示对神经性痛觉的抗痛觉活性[2]。 Animal Model: BALB/c mice; tonic, phasic and Capsaicin (HY-10448) nociception model[2] Dosage: 10, 25, 50, and 75 mg/kg Administration: IP, single dose Result: Produced a significant protection on tonic, phasic and capsaicin nociception in a dose-dependent manner. Animal Model: BALB/c mice, Oxaliplatin (HY-17371)-induced neuropathic nociception model[2] Dosage: 50 and 75 mg/kg Administration: IP, single dose Result: Significantly attenuated the paw withdrawal threshold changes associated with Oxaliplatin. Significantly increased the percent antinociception during 30-120 min. |
| References |
| Density | 1.406g/cm3 |
|---|---|
| Boiling Point | 427.3ºC at 760mmHg |
| Melting Point | 280-284°C |
| Molecular Formula | C14H12N2O3 |
| Molecular Weight | 256.25700 |
| Flash Point | 212.2ºC |
| Exact Mass | 256.08500 |
| PSA | 81.92000 |
| LogP | 2.25260 |
| Appearance of Characters | solid | off-white |
| Index of Refraction | 1.615 |
| Storage condition | Store at RT |
| Water Solubility | DMSO: ~20 mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2928000090 |
| Precursor 2 | |
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| DownStream 1 | |
CAS#:90-02-8
CAS#:936-02-7![(6Z)-6-[(5E)-5-(6-oxocyclohexa-2,4-dien-1-ylidene)-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one structure](https://www.chemsrc.com/caspic/308/2491-96-5.png)
CAS#:2491-96-5| HS Code | 2928000090 |
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| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: quantitative structure-activity relationships.
J. Inorg. Biochem. 77 , 125-133 , (1999) A series of salicylaldehyde benzoylhydrazone derivatives, their copper(II) complexes and a range of transition metal complexes of the unsubstituted ligand has been synthesized and evaluated for cytoto... |
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Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.
Br. J. Pharmacol. 142 , 97-106 , (2004) 1. A high-throughput assay utilizing the voltage/ion probe reader (VIPR) technology identified salicylidene salicylhydrazide (SCS) as being a potent selective inhibitor of alpha2beta1gamma1 GABA(A) re... |
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GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells.
FEBS Lett. 584(6) , 1193-8, (2010) Gamma-aminobutyric acid type A (GABAA) receptor beta1 (gabrb1), a subunit of GABAA receptors involved in inhibitory effects on neurotransmission, was found to associate with the formation of protease-... |
| 2-hydroxybenzoylhydrazone of 2-hydroxybenzoylhydrazine |
| SCS |
| salicylaldehyde o-hydroxybenzoylhydrazone |
| MFCD00043494 |
| N'-Salicylidenesalicylic hydrazide |
| SALICYLIDENE SALICYLHYDRAZONE |
| salicylaldehyde 2-hydroxybenzoylhydrazone |
| 1-Salicylidene-2-salicyloylhydrazine |
| EINECS 221-773-2 |
| Salicylidene salicylhydrazide |
| 1-Salicyloyl-2-salicylidenehydrazine |
| SALICYLIC (2-HYDROXYBENZYLIDENE)HYDRAZIDE |
| 2-HYDROXYBENZYLIDENE SALICYLHYDRAZIDE |
| 2-hydroxybenzoylhydrazine 2-hydroxybenzoylhydrazone |
| 2-Hydroxybenzylidene 2-hydroxybenzhydrazide |