Stearoyl-L-carnitine chloride

• 常用名: Stearoyl-L-carnitine chloride
• 英文名: Stearoyl-L-carnitine chloride
• CAS号: 32350-57-5
• 分子量: 464.122
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₅₀ClNO₄
• 熔点: N/A
• 闪点: N/A

Stearoyl-L-carnitine chloride用途

Stearoyl-L-carnitine chloride 是一种内源性的长链酰基肉碱。Stearoyl-L-carnitine chloride 是一种效力较弱的 GlyT2 抑制剂。Stearoyl-L-carnitine chloride 在浓度高达 3 μM 时可抑制 16.8％ 的甘氨酸响应。

Stearoyl-L-carnitine chloride名称

• 中文名: 硬脂酰-L-肉碱-d3盐酸盐
• 英文名: (2R)-3-Carboxy-N,N,N-trimethyl-2-(stearoyloxy)-1-propanaminium chloride

Stearoyl-L-carnitine chloride生物活性

• 描述: Stearoyl-L-carnitine chloride 是一种内源性的长链酰基肉碱。Stearoyl-L-carnitine chloride 是一种效力较弱的 GlyT2 抑制剂。Stearoyl-L-carnitine chloride 在浓度高达 3 μM 时可抑制 16.8％ 的甘氨酸响应。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 跨膜转运 >> GLYT
  信号通路 >> 神经信号通路 >> GLYT
• 靶点实验:

  GlyT2

• 体外研究: 硬脂酰左旋肉碱(0.01-10μM) 抑制甘氨酸(30μM) 浓度上升3.5%时,转运率为16.8%μM在非洲爪蟾卵母细胞中的表达[2]。硬脂酰左旋肉碱(500μ米；30分钟)抑制HPCT细胞对钠依赖性[3H]肉碱(20 nM)的摄取约50%[3]。
• 体内研究: 硬脂酰左旋肉碱在阿尔茨海默病(AD)、轻度认知障碍(MCI)和主观记忆主诉(SMC)中显著降低[1]。
• 参考文献:

  [1]. Cristofano A, et, al. Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. PLoS One. 2016 May 19;11(5):e0155694.

  [2]. Carland JE, et, al. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Br J Pharmacol. 2013 Feb;168(4):891-902.

  [3]. Huang W, et, al. Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. Biochem Pharmacol. 1999 Oct 15;58(8):1361-70.

Stearoyl-L-carnitine chloride物理化学性质

• 分子式: C₂₅H₅₀ClNO₄
• 分子量: 464.122
• 精确质量: 463.342834
• InChIKey: YSVYWVPJJXVIFM-GNAFDRTKSA-N
• SMILES: CCCCCCCCCCCCCCCCCC(=O)OC(CC(=O)O)C[N+](C)(C)C.[Cl-]
• 储存条件: -20°C，干燥，密封

Stearoyl-L-carnitine chloride安全信息

• 危害码 (欧洲): Xi

Stearoyl-L-carnitine chloride靶点实验

查看更多实验

实验名称：Minimal inhibitory concentration against Aspergillus fumigatus 来源：ChEMBL 靶标：Aspergillus fumigatus External Id：CHEMBL652273

实验名称：Minimal inhibitory concentration against Mucor mucedo 来源：ChEMBL 靶标：Mucor mucedo External Id：CHEMBL878555

实验名称：Minimal inhibitory concentration against Streptococcus faecalis 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL812155

实验名称：Minimal inhibitory concentration against Proteus vulgaris 来源：ChEMBL 靶标：Proteus vulgaris External Id：CHEMBL767457

实验名称：Minimal inhibitory concentration against Candida albicans 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL659876

实验名称：Minimal inhibitory concentration against Saccharomyces cerevisiae 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL803013

实验名称：Minimal inhibitory concentration against Staphylococcus aureus 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL810471

实验名称：Minimal inhibitory concentration against Aspergillus niger 来源：ChEMBL 靶标：Aspergillus niger External Id：CHEMBL649551

实验名称：Calculated partition coefficient (clogP) 来源：ChEMBL 靶标：N/A External Id：CHEMBL631234

实验名称：Minimal inhibitory concentration against Escherichia coli 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL878402

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Stearoyl-L-carnitine chloride英文别名

• 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-[(1-oxooctadecyl)oxy]-, chloride, (2R)- (1:1)
• (2R)-3-Carboxy-N,N,N-trimethyl-2-(stearoyloxy)-1-propanaminium chloride
• (2R)-3-carboxy-N,N,N-trimethyl-2-(octadecanoyloxy)propan-1-aminium chloride