Oleuropein

Modify Date: 2024-01-02 10:51:00

Oleuropein structure	Common Name	Oleuropein
	CAS Number	32619-42-4	Molecular Weight	540.514
	Density	1.5±0.1 g/cm3	Boiling Point	772.9±60.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₃₂O₁₃	Melting Point	89-90ºC
	MSDS	Chinese USA	Flash Point	257.0±26.4 °C

Use of Oleuropein

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].

Name	Oleuropein
Synonym	More Synonyms

Description	Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Signaling Pathways >> Others >> Aromatase
Target	PPARγ Apoptosis Aromatase
In Vitro	Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy[2].
References	[1]. Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376. [2]. Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3). pii: E686.

Density	1.5±0.1 g/cm3
Boiling Point	772.9±60.0 °C at 760 mmHg
Melting Point	89-90ºC
Molecular Formula	C₂₅H₃₂O₁₃
Molecular Weight	540.514
Flash Point	257.0±26.4 °C
Exact Mass	540.184265
PSA	201.67000
LogP	-0.91
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.630
Storage condition	room temp

Oleuropein MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	2938909090

Precursor 0
DownStream 2
CAS#:10597-60-1 2-(3,4-Dihydrox... CAS#:178600-68-5 Oleoside

HS Code	2938909090

Rapid screening of oleuropein from olive leaves using matrix solid-phase dispersion and high-performance liquid chromatography.

J. AOAC Int. 97(4) , 1109-13, (2014)

Matrix solid-phase dispersion (MSPD) methodology as a quick and easy extraction method has been developed to extract oleuropein from Olea europaea leaves. This method has been compared with convention...

A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS.

J. Pharm. Biomed. Anal. 72 , 121-6, (2013)

Olive leaves, an easily available natural low-cost material, constitute a source of extracts with significant antitumor activity that inhibits cell proliferation in several breast-cancer-cell models. ...

Antiproliferative effect of oleuropein in prostate cell lines.

Int. J. Oncol. 41(1) , 31-8, (2012)

Currently, there is increasing interest in the in vivo protective effects of natural antioxidants found in dietary plants against oxidative damage caused by free radical species. Oxidative stress has ...

Olive Leaf Extract

MFCD00017493

Oleuropein

oleuropein glucoside

EINECS 251-129-6

Methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-2H-pyran-5-carboxylate

2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(3,4-dihydroxyphenyl)ethyl ester, (2S,3E,4S)-

BioBioPha
China
Product Name: Oleuropein
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Oleuropein
Price: ￥738.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Oleuropein
Price: $350.0/100mg $700.0/250mg $1400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Oleuropein
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Oleuropein
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Oleuropein

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