6-Carboxyfluorescein
6-Carboxyfluorescein structure
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Common Name | 6-Carboxyfluorescein | ||
|---|---|---|---|---|
| CAS Number | 3301-79-9 | Molecular Weight | 376.316 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 736.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H12O7 | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 271.0±26.4 °C | |
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TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity.
Oncotarget 5(18) , 8107-22, (2014) p53 plays a key role in regulating DNA damage response by suppressing cell cycle progression or inducing apoptosis depending on extent of DNA damage. However, it is not clear why mild genotoxic stress favors growth arrest, whereas excessive lesions signal cel... |
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Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response.
Infect. Immun. 83(2) , 591-603, (2015) The complement system is a key component of the host immune response for the recognition and clearance of Streptococcus pneumoniae. In this study, we demonstrate that the amidase LytA, the main pneumococcal autolysin, inhibits complement-mediated immunity ind... |
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Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.
Exp. Cell Res. 338 , 251-60, (2015) Cellular levels of inhibitor of apoptosis (IAP) proteins are elevated in multiple human cancers and their activities often play a part in promoting cancer cell survival by blocking apoptotic pathways, controlling signal transduction pathways and contributing ... |
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Human leukocyte antigen-G polymorphisms influence the clinical outcome in diffuse large B-cell lymphoma.
Genes Chromosomes Cancer 54(3) , 185-93, (2015) The role of HLA-G is extensively studied in cancer due to its inhibition of the immune response. Several polymorphisms in the HLA-G gene have been reported to significantly affect its expression. We, therefore, investigated whether functionally relevant HLA-G... |
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A Novel Binary Mixture of Helicoverpa armigera Single Nucleopolyhedrovirus Genotypic Variants Has Improved Insecticidal Characteristics for Control of Cotton Bollworms.
Appl. Environ. Microbiol. 81 , 3984-93, (2015) The genotypic diversity of two Spanish isolates of Helicoverpa armigera single nucleopolyhedrovirus (HearSNPV) was evaluated with the aim of identifying mixtures of genotypes with improved insecticidal characteristics for control of the cotton bollworm. Two g... |
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Clinical relevance of KRAS-mutated subclones detected with picodroplet digital PCR in advanced colorectal cancer treated with anti-EGFR therapy.
Clin. Cancer Res. 21(5) , 1087-97, (2015) KRAS mutations are predictive of nonresponse to anti-EGFR therapies in metastatic colorectal cancer (mCRC). However, only 50% of nonmutated patients benefit from them. KRAS-mutated subclonal populations nondetectable by conventional methods have been suggeste... |
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A novel assay for detecting fusion pore formation: implications for the fusion mechanism.
Biochemistry 52(47) , 8510-7, (2013) Membrane fusion is broadly envisioned as a two- or three-step process proceeding from contacting bilayers through one or two semistable, nonlamellar lipidic intermediate structures to a fusion pore. A true fusion event requires mixing of contents between comp... |
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Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.
PLoS ONE 9(8) , e104113, (2014) The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes. In this work, we demonstrate that tannic acid modified silver na... |
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Mucosal effects of tenofovir 1% gel.
Elife 4 , (2015) Tenofovir gel is being evaluated for vaginal and rectal pre-exposure prophylaxis against HIV transmission. Because this is a new prevention strategy, we broadly assessed its effects on the mucosa. In MTN-007, a phase-1, randomized, double-blinded rectal micro... |
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A microsatellite-based genetic linkage map and putative sex-determining genomic regions in Lake Victoria cichlids.
Gene 560(2) , 156-64, (2015) Cichlid fishes in East Africa have undergone extensive adaptive radiation, which has led to spectacular diversity in their morphology and ecology. To date, genetic linkage maps have been constructed for several tilapias (riverine), Astatotilapia burtoni (Lake... |