Indirubin-3'-monoxime-5-sulphonic acid

Modify Date: 2025-08-27 08:28:49

Indirubin-3'-monoxime-5-sulphonic acid Structure
Indirubin-3'-monoxime-5-sulphonic acid structure
 Common Name Indirubin-3'-monoxime-5-sulphonic acid
CAS Number 331467-05-1 Molecular Weight 357.34
Density N/A Boiling Point N/A
Molecular Formula C16H11N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Indirubin-3'-monoxime-5-sulphonic acid


Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].

 Names

Name 3-[3-(hydroxyamino)-1H-indol-2-yl]-2-oxoindole-5-sulfonic acid
Synonym More Synonyms

 Indirubin-3'-monoxime-5-sulphonic acid Biological Activity

Description Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].
Related Catalog
Target

CDK1:5 nM (IC50)

CDK5:7 nM (IC50)

GSK-3β:80 nM (IC50)

References

[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.

 Chemical & Physical Properties

Molecular Formula C16H11N3O5S
Molecular Weight 357.34
Exact Mass 357.04200
PSA 140.23000
LogP 1.16390

 Synonyms

3-[3-(Hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid
indirubin-3'-monoxime-5-sulphonic acid
A05-A11B1-II
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