Indirubin-3'-monoxime-5-sulphonic acid

Modify Date: 2025-08-27 08:28:49

Indirubin-3'-monoxime-5-sulphonic acid Structure
Indirubin-3'-monoxime-5-sulphonic acid structure
 Common Name Indirubin-3'-monoxime-5-sulphonic acid
CAS Number 331467-05-1 Molecular Weight 357.34
Density N/A Boiling Point N/A
Molecular Formula C16H11N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Indirubin-3'-monoxime-5-sulphonic acid


Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].

 Names

Name 3-[3-(hydroxyamino)-1H-indol-2-yl]-2-oxoindole-5-sulfonic acid
Synonym More Synonyms

 Indirubin-3'-monoxime-5-sulphonic acid Biological Activity

Description Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].
Related Catalog
Target

CDK1:5 nM (IC50)

CDK5:7 nM (IC50)

GSK-3β:80 nM (IC50)

References

[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.

 Chemical & Physical Properties

Molecular Formula C16H11N3O5S
Molecular Weight 357.34
Exact Mass 357.04200
PSA 140.23000
LogP 1.16390

 Synonyms

3-[3-(Hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid
indirubin-3'-monoxime-5-sulphonic acid
A05-A11B1-II
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Indirubin-3'-monoxime-5-sulphonic acid suppliers

Indirubin-3'-monoxime-5-sulphonic acid price

Related Compounds: More...
Indirubin-3'-monoxime
160807-49-8
Alizarin fluorine blue-5-sulphonic acid
55671-62-0
5-Iodo-indirubin-3'-monoxime
331467-03-9
acenaphthene-5-sulphonic acid
53700-79-1
8-MERCAPTOQUINOLINE-5-SULPHONIC ACID
5825-36-5
8-hydroxyquinoline-5-sulphonic acid, compound with 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one (1:1)
16509-13-0
8-hydroxyquinoline-5-sulphonic acid, compound with trimethylamine (1:1)
71672-84-9
2-Diazo-1-naphtol-5-sulphonic acid
23890-27-9
2-[(methylthio)methyl]-1H-benzimidazole-5-sulphonic acid
29490-03-7
3-chloro-N-{4-[4-(propan-2-yl)phenyl]-1,2,5-oxadiazol-3-yl}-1-benzothiophene-2-carboxamide
951958-66-0
N-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-4-methoxy-1H-indole-2-carboxamide
951943-19-4
7-methoxy-N-(2-oxo-2H-chromen-6-yl)-1-benzofuran-2-carboxamide
951943-27-4
methyl N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[(4-methylphenyl)acetyl]glycinate
951958-78-4
N-{4,5-dimethyl-3-[(4-methylphenyl)sulfonyl]-1-(2-methylpropyl)-1H-pyrrol-2-yl}furan-2-carboxamide
951943-30-9
2-[3-[(2-chlorobenzyl)sulfanyl]-5-(3-pyridinyl)-4H-1,2,4-triazol-4-yl]ethanol
947866-44-6
(3,5-dimethoxyphenyl)[4-(1H-indol-2-ylcarbonyl)piperazin-1-yl]methanone
951943-45-6
3-(3,4-dimethoxyphenyl)-9-(3-methoxypropyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one
951959-02-7
N~2~-[4-(3-chloro-4-methoxyanilino)-4-oxobutyl]-5-methoxy-1-methyl-1H-indole-2-carboxamide
951959-14-1
6-benzyl-3-(3-isobutyl-1H-pyrazol-5-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
1050290-39-5
Chemsrc provides Indirubin-3'-monoxime-5-sulphonic acid(CAS#:331467-05-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Indirubin-3'-monoxime-5-sulphonic acid are included as well.>> amp version: Indirubin-3'-monoxime-5-sulphonic acid

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved